Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia
We explored the mean differences in routinely measured lipids (total cholesterol, triglycerides, and high-density lipoprotein cholesterol) according to exposure to different combination antiretroviral regimens in Asian (n=2051) and Australian (predominantly Caucasian, n=794) cohorts. The regimen was...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/246280 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396066006335488 |
|---|---|
| author | Amit C. Achhra Janaki Amin Jennifer Hoy Junko Tanuma Thira Sirisanthana David Nolan Tuti Merati Michelle Giles |
| author_facet | Amit C. Achhra Janaki Amin Jennifer Hoy Junko Tanuma Thira Sirisanthana David Nolan Tuti Merati Michelle Giles |
| author_sort | Amit C. Achhra |
| collection | DOAJ |
| description | We explored the mean differences in routinely measured lipids (total cholesterol, triglycerides, and high-density lipoprotein cholesterol) according to exposure to different combination antiretroviral regimens in Asian (n=2051) and Australian (predominantly Caucasian, n=794) cohorts. The regimen was defined as at least 3 antiretroviral drugs with at least 2 nucleoside-reverse transcriptases (NRTIs) and either of at least one protease inhibitor (PI) or non-nucleoside-reverse transcriptases (NNRTIs). We categorised cART regimens as: NRTIs as tenofovir based or not; NNRTIs as nevirapine or efavirenz (but not both); and PI as atazanavir based or not. We found that the impact of various antiretroviral regimens on lipids in Asian and Australian cohorts was only different by cohort for total cholesterol (P for interaction between regimen and cohort: <0.001) but not in case of other lipids (P for interaction: >0.05). The differences in total cholesterol were however small and unlikely to be of clinical significance. Overall, tenofovir with nevirapine or atazanavir was associated with the most favorable lipids, while the PI regimens without tenofovir and atazanavir were associated with least favorable lipids. We conclude that the impact of various ART regimens on lipids is largely similar in Asian and Australian cohorts and that the newer drugs such as tenofovir and atazanavir are likely to provide similar benefit in terms of lipid profiles in both populations. |
| format | Article |
| id | doaj-art-b56e06215b0d443da3ba4895f24ec621 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-b56e06215b0d443da3ba4895f24ec6212025-08-20T03:39:26ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/246280246280Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and AustraliaAmit C. Achhra0Janaki Amin1Jennifer Hoy2Junko Tanuma3Thira Sirisanthana4David Nolan5Tuti Merati6Michelle Giles7The Kirby Institute for Infection and Immunity in Society (Formerly the National Centre in HIV Epidemiology and Clinical Research), Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaThe Kirby Institute for Infection and Immunity in Society (Formerly the National Centre in HIV Epidemiology and Clinical Research), Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaInfectious Diseases Unit, Alfred Hospital and Monash University, Melbourne, VIC 3004, AustraliaAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo 162-8655, JapanResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, ThailandCentre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, AustraliaFaculty of Medicine, Udayana University and Sanglah Hospital, Bali 80233, IndonesiaInfectious Diseases Unit, Alfred Hospital and Monash University, Melbourne, VIC 3004, AustraliaWe explored the mean differences in routinely measured lipids (total cholesterol, triglycerides, and high-density lipoprotein cholesterol) according to exposure to different combination antiretroviral regimens in Asian (n=2051) and Australian (predominantly Caucasian, n=794) cohorts. The regimen was defined as at least 3 antiretroviral drugs with at least 2 nucleoside-reverse transcriptases (NRTIs) and either of at least one protease inhibitor (PI) or non-nucleoside-reverse transcriptases (NNRTIs). We categorised cART regimens as: NRTIs as tenofovir based or not; NNRTIs as nevirapine or efavirenz (but not both); and PI as atazanavir based or not. We found that the impact of various antiretroviral regimens on lipids in Asian and Australian cohorts was only different by cohort for total cholesterol (P for interaction between regimen and cohort: <0.001) but not in case of other lipids (P for interaction: >0.05). The differences in total cholesterol were however small and unlikely to be of clinical significance. Overall, tenofovir with nevirapine or atazanavir was associated with the most favorable lipids, while the PI regimens without tenofovir and atazanavir were associated with least favorable lipids. We conclude that the impact of various ART regimens on lipids is largely similar in Asian and Australian cohorts and that the newer drugs such as tenofovir and atazanavir are likely to provide similar benefit in terms of lipid profiles in both populations.http://dx.doi.org/10.1155/2012/246280 |
| spellingShingle | Amit C. Achhra Janaki Amin Jennifer Hoy Junko Tanuma Thira Sirisanthana David Nolan Tuti Merati Michelle Giles Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia AIDS Research and Treatment |
| title | Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia |
| title_full | Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia |
| title_fullStr | Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia |
| title_full_unstemmed | Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia |
| title_short | Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia |
| title_sort | differences in lipid measurements by antiretroviral regimen exposure in cohorts from asia and australia |
| url | http://dx.doi.org/10.1155/2012/246280 |
| work_keys_str_mv | AT amitcachhra differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT janakiamin differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT jenniferhoy differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT junkotanuma differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT thirasirisanthana differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT davidnolan differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT tutimerati differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia AT michellegiles differencesinlipidmeasurementsbyantiretroviralregimenexposureincohortsfromasiaandaustralia |