A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells

A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells

Abstract Circulating melanoma cells (CMCs) are responsible for the hematogenous spread of melanoma and, ultimately, metastasis. However, their study has been limited by the low abundance in patient blood and the heterogeneous expression of surface markers. The FDA-approved CellSearch platform enrich...

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Main Authors: Cristina Poggiana, Alessandro Francesco Piazza, Cristina Catoni, Ilaria Gallingani, Luisa Piccin, Stefania Pellegrini, Vittorio Aneloni, Valentina Salizzato, Jacopo Pigozzo, Alessio Fabozzi, Antonella Facchinetti, Chiara Menin, Paolo del Fiore, Simone Mocellin, Vanna Chiarion-Sileni, Antonio Rosato, Maria Chiara Scaini
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Liquid biopsy
Circulating melanoma cells (CMCs)
Melanoma
Parsortix PC1 system
CMC genetic analysis
CMC phenotypic analysis
Online Access:https://doi.org/10.1038/s41598-025-99153-y
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