Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promo...

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Bibliographic Details
Main Authors: Selena G Burgess, Isabel Peset, Nimesh Joseph, Tommaso Cavazza, Isabelle Vernos, Mark Pfuhl, Fanni Gergely, Richard Bayliss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005345&type=printable
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