Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms
Ulcerative colitis is a type of inflammatory bowel disease (IBD) that has risen around the world in recent years. Diet, lifestyle, genetics, stress, are the risk factors of ulcerative colitis. Indeed, oxidative stress, impairment of the intestinal barrier, inflammation, and dysbiosis of gut microbio...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000325 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864428046581760 |
|---|---|
| author | Najmeh Oliyaei Saghar Zekri Aida Iraji Alireza Oliyaei Romina Tanideh Nadiar M. Mussin Amin Tamadon Nader Tanideh |
| author_facet | Najmeh Oliyaei Saghar Zekri Aida Iraji Alireza Oliyaei Romina Tanideh Nadiar M. Mussin Amin Tamadon Nader Tanideh |
| author_sort | Najmeh Oliyaei |
| collection | DOAJ |
| description | Ulcerative colitis is a type of inflammatory bowel disease (IBD) that has risen around the world in recent years. Diet, lifestyle, genetics, stress, are the risk factors of ulcerative colitis. Indeed, oxidative stress, impairment of the intestinal barrier, inflammation, and dysbiosis of gut microbiota are the main pathways involved in ulcerative colitis. Therefore, using the anti-inflammatory and antioxidant ingredients can modulate the ulcerative colitis symptoms. Recent investigations in functional foods have demonstrated that diet and fortified foods play major therapeutic effects in human health, thus, the natural remedies have become an attractive approach. Among various natural substances, algae and marine products are valuable sources and rich in a wide range of metabolites with biological activities that can ameliorate ulcerative colitis signs. It has been reported that algal sulfated polysaccharides, peptides, pigments, polyphenols, and marine oil are useful for controlling ulcerative colitis via different pathways including modulating of TNF-α and other related inflammatory cytokines secretion, increasing the antioxidant enzymes [superoxide dismutase (SOD) and catalase(CAT)] activities, reduction of myeloperoxidase (MPO) activity and malondialdehyde (MDA) production, improving the intestinal barrier function and repairing histological damage in the colon. This review focused on the pathology of ulcerative colitis, pathogenesis and key inflammatory pathways, and the role of algae and marine-based metabolites for reduction of ulcerative colitis signs via alleviating the inflammation cytokines secretion, and improving the barrier function and gut microbiota. |
| format | Article |
| id | doaj-art-b565a30a0e5e4655825caa445b8acaa6 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-b565a30a0e5e4655825caa445b8acaa62025-02-09T04:59:58ZengElsevierJournal of Functional Foods1756-46462025-02-01125106690Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptomsNajmeh Oliyaei0Saghar Zekri1Aida Iraji2Alireza Oliyaei3Romina Tanideh4Nadiar M. Mussin5Amin Tamadon6Nader Tanideh7Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Seafood Processing Research Center, School of Agriculture, Shiraz University, Shiraz, IranDepartment of Cell Biology, Faculty of Arts and Science, department of Cell Biology, University of Toronto 27 King's College Cir, Toronto, On M5S 1A1, CanadaDepartment of Persian Medicine, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Nursing and Paramedical Sciences, Jahrom University of Medical Sciences, Jahrom, Iran,Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery No. 2, West Kazakhstan Medical University, Aktobe, KazakhstanStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan; Corresponding authors at: Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding authors at: Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Ulcerative colitis is a type of inflammatory bowel disease (IBD) that has risen around the world in recent years. Diet, lifestyle, genetics, stress, are the risk factors of ulcerative colitis. Indeed, oxidative stress, impairment of the intestinal barrier, inflammation, and dysbiosis of gut microbiota are the main pathways involved in ulcerative colitis. Therefore, using the anti-inflammatory and antioxidant ingredients can modulate the ulcerative colitis symptoms. Recent investigations in functional foods have demonstrated that diet and fortified foods play major therapeutic effects in human health, thus, the natural remedies have become an attractive approach. Among various natural substances, algae and marine products are valuable sources and rich in a wide range of metabolites with biological activities that can ameliorate ulcerative colitis signs. It has been reported that algal sulfated polysaccharides, peptides, pigments, polyphenols, and marine oil are useful for controlling ulcerative colitis via different pathways including modulating of TNF-α and other related inflammatory cytokines secretion, increasing the antioxidant enzymes [superoxide dismutase (SOD) and catalase(CAT)] activities, reduction of myeloperoxidase (MPO) activity and malondialdehyde (MDA) production, improving the intestinal barrier function and repairing histological damage in the colon. This review focused on the pathology of ulcerative colitis, pathogenesis and key inflammatory pathways, and the role of algae and marine-based metabolites for reduction of ulcerative colitis signs via alleviating the inflammation cytokines secretion, and improving the barrier function and gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464625000325Seaweed, Fucoidan, Fucoxanthin, Fish oil, Inflammatory bowel disease, Ulcerative colitis. |
| spellingShingle | Najmeh Oliyaei Saghar Zekri Aida Iraji Alireza Oliyaei Romina Tanideh Nadiar M. Mussin Amin Tamadon Nader Tanideh Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms Journal of Functional Foods Seaweed, Fucoidan, Fucoxanthin, Fish oil, Inflammatory bowel disease, Ulcerative colitis. |
| title | Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms |
| title_full | Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms |
| title_fullStr | Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms |
| title_full_unstemmed | Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms |
| title_short | Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms |
| title_sort | health benefits of algae and marine derived bioactive metabolites for modulating ulcerative colitis symptoms |
| topic | Seaweed, Fucoidan, Fucoxanthin, Fish oil, Inflammatory bowel disease, Ulcerative colitis. |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000325 |
| work_keys_str_mv | AT najmeholiyaei healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT sagharzekri healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT aidairaji healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT alirezaoliyaei healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT rominatanideh healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT nadiarmmussin healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT amintamadon healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms AT nadertanideh healthbenefitsofalgaeandmarinederivedbioactivemetabolitesformodulatingulcerativecolitissymptoms |