Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making
Abstract This study aimed to explore whether ultra-early indicators can predict the severity of acute hypertriglyceridemic pancreatitis (HTGP) and guide clinical decisions. This retrospective study analyzed data from HTGP patients who were categorized into mild acute pancreatitis (MAP) and moderatel...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85847-w |
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| author | Jing Wu Yizhi Liang Xiaoting Tang Zilan Rao Chaowei Li Xiaoping Pan Taiyong Fang |
| author_facet | Jing Wu Yizhi Liang Xiaoting Tang Zilan Rao Chaowei Li Xiaoping Pan Taiyong Fang |
| author_sort | Jing Wu |
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| description | Abstract This study aimed to explore whether ultra-early indicators can predict the severity of acute hypertriglyceridemic pancreatitis (HTGP) and guide clinical decisions. This retrospective study analyzed data from HTGP patients who were categorized into mild acute pancreatitis (MAP) and moderately severe/severe acute pancreatitis (MSAP/SAP) groups based on their final clinical outcomes. Ultra-early indicators (serum calcium, triglyceride [TG], interleukin-6 [IL-6], D-dimer, hemoglobin A1c [HbA1c], arterial lactate) were measured within 6 h of admission. Among 110 patients, 56 had MAP and 54 had MSAP/SAP. Within 6 h of admission, TG, IL-6, D-dimer, HbA1c, and arterial lactate levels were significantly higher in the MSAP/SAP group, while serum calcium was lower. Multivariable logistic regression and receiver operator characteristic curve identified IL-6, D-dimer, and serum calcium as independent risk factors and ultra-early predictors of HTGP severity. Patients with MSAP/SAP who received blood purification within 24 h had a shorter hospital stay compared to those treated later. IL-6, D-dimer, and serum calcium are promising biomarkers for early prediction of HTGP severity. Early blood purification within 24 h reduces complications and hospital stay in MSAP/SAP patients, while traditional treatments remain effective for MAP patients, potentially reducing medical costs. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b553917b3c6e448d95ecb28e528f38282025-01-12T12:23:59ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-85847-wUltra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-makingJing Wu0Yizhi Liang1Xiaoting Tang2Zilan Rao3Chaowei Li4Xiaoping Pan5Taiyong Fang6Department of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityDepartment of Gastroenterology, the Second Affiliated Hospital, Fujian Medical UniversityAbstract This study aimed to explore whether ultra-early indicators can predict the severity of acute hypertriglyceridemic pancreatitis (HTGP) and guide clinical decisions. This retrospective study analyzed data from HTGP patients who were categorized into mild acute pancreatitis (MAP) and moderately severe/severe acute pancreatitis (MSAP/SAP) groups based on their final clinical outcomes. Ultra-early indicators (serum calcium, triglyceride [TG], interleukin-6 [IL-6], D-dimer, hemoglobin A1c [HbA1c], arterial lactate) were measured within 6 h of admission. Among 110 patients, 56 had MAP and 54 had MSAP/SAP. Within 6 h of admission, TG, IL-6, D-dimer, HbA1c, and arterial lactate levels were significantly higher in the MSAP/SAP group, while serum calcium was lower. Multivariable logistic regression and receiver operator characteristic curve identified IL-6, D-dimer, and serum calcium as independent risk factors and ultra-early predictors of HTGP severity. Patients with MSAP/SAP who received blood purification within 24 h had a shorter hospital stay compared to those treated later. IL-6, D-dimer, and serum calcium are promising biomarkers for early prediction of HTGP severity. Early blood purification within 24 h reduces complications and hospital stay in MSAP/SAP patients, while traditional treatments remain effective for MAP patients, potentially reducing medical costs.https://doi.org/10.1038/s41598-025-85847-wHypertriglyceridemic pancreatitisUltra-early indicatorsBiomarkersEmergency medicineTherapy |
| spellingShingle | Jing Wu Yizhi Liang Xiaoting Tang Zilan Rao Chaowei Li Xiaoping Pan Taiyong Fang Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making Scientific Reports Hypertriglyceridemic pancreatitis Ultra-early indicators Biomarkers Emergency medicine Therapy |
| title | Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making |
| title_full | Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making |
| title_fullStr | Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making |
| title_full_unstemmed | Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making |
| title_short | Ultra-early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision-making |
| title_sort | ultra early indicators of acute hypertriglyceridemic pancreatitis may influence treatment decision making |
| topic | Hypertriglyceridemic pancreatitis Ultra-early indicators Biomarkers Emergency medicine Therapy |
| url | https://doi.org/10.1038/s41598-025-85847-w |
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