Electrochemical Sensor Based on Co-MOF for the Detection of Dihydromyricetin in <i>Ampelopsis grossedentata</i>
Dihydromyricetin (DMY), as the main active ingredient in <i>Ampelopsis grossedentata</i>, is a naturally occurring flavonoid that has attracted extensive attention for its multiple biological activities. For the quick and accurate measurement of DMY, a novel electrochemical sensor based...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/180 |
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| Summary: | Dihydromyricetin (DMY), as the main active ingredient in <i>Ampelopsis grossedentata</i>, is a naturally occurring flavonoid that has attracted extensive attention for its multiple biological activities. For the quick and accurate measurement of DMY, a novel electrochemical sensor based on a glassy carbon electrode (GCE) modified with a cobalt metal-organic framework (Co-MOF) was proposed in this work. The Co-MOF was synthesized via a single-step hydrothermal process using Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O. Fourier infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy were used to study the morphology and structure of the synthesized Co-MOF. Utilizing differential pulse voltammetry and cyclic voltammetry methods, the effectiveness of DMY electro-oxidation on the Co-MOF/GCE was examined. The results showed that, in comparison to the bare GCE, the electro-oxidation peak current of DMY was considerably increased by the Co-MOF/GCE. The detection limit was 0.07 μM, and the peak current demonstrated two linear relationships in the ranges of 0.2−20 μM and 20−100 μM, with the linear equations of Ip (μA) = 0.4729c (μM) + 1.0822 (R<sup>2</sup> = 0.9913) and Ip (μA) = 0.0939c (μM) + 8.4178 (R<sup>2</sup> = 0.9971), respectively. The average DMY content in <i>Ampelopsis grossedentata</i> samples was measured to be 3.275 μM, with a good recovery of 108.27% and a relative standard deviation value of 3.46%. The proposed method is simple, rapid and sensitive and can be used for the determination of DMY in <i>Ampelopsis grossedentata</i>. |
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| ISSN: | 1420-3049 |