Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment
Abstract This study aimed to identify morphologic and functional differences in the parasagittal dural space (PSD) between patients with mild cognitive impairment (MCI) and cognitively unimpaired participants using dynamic contrast-enhanced MRI (DCE MRI). A total of 29 MCI patients and nine controls...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-07909-3 |
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| author | Bio Joo Mina Park Song Soo Kim Sung Jun Ahn Han-Kyeol Kim Hanna Cho Chul Hyoung Lyoo Sang Hyun Suh |
| author_facet | Bio Joo Mina Park Song Soo Kim Sung Jun Ahn Han-Kyeol Kim Hanna Cho Chul Hyoung Lyoo Sang Hyun Suh |
| author_sort | Bio Joo |
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| description | Abstract This study aimed to identify morphologic and functional differences in the parasagittal dural space (PSD) between patients with mild cognitive impairment (MCI) and cognitively unimpaired participants using dynamic contrast-enhanced MRI (DCE MRI). A total of 29 MCI patients and nine controls underwent structural MRI and DCE MRI, where PSD volume and parameters such as peak wash-in rate and time to first peak enhancement were assessed. MCI patients had significantly larger PSD volume (P = 0.023), a lower peak wash-in rate (P < 0.001), and delayed time to first peak (P = 0.001) compared to controls. In multivariate regression analysis, PSD volume (β = -0.579, 95% CI [-1.072 – -0.086], P = 0.023) and wash-out rate (β = -3.293, 95% CI [-6.351 – -0.235], P = 0.036) were significantly associated with the Mini-Mental State Examination (MMSE) score. Additionally, a lower peak wash-in rate correlated significantly with lower cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA) (P = 0.043). This association highlights a potential link between meningeal lymphatic dysfunction and cognitive decline, suggesting that PSD alterations could reflect early stages of neurodegenerative changes. In conclusion, these PSD structural and functional alterations in MCI patients may serve as early imaging markers, helping in the assessment of disease severity in neurodegenerative conditions such as Alzheimer’s disease. This insight into meningeal lymphatic dysfunction provides a promising direction for early diagnosis and monitoring of cognitive impairment. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-b54f416e43af47b69e6fec8bf1519db82025-08-20T04:01:23ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-07909-3Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairmentBio Joo0Mina Park1Song Soo Kim2Sung Jun Ahn3Han-Kyeol Kim4Hanna Cho5Chul Hyoung Lyoo6Sang Hyun Suh7Department of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract This study aimed to identify morphologic and functional differences in the parasagittal dural space (PSD) between patients with mild cognitive impairment (MCI) and cognitively unimpaired participants using dynamic contrast-enhanced MRI (DCE MRI). A total of 29 MCI patients and nine controls underwent structural MRI and DCE MRI, where PSD volume and parameters such as peak wash-in rate and time to first peak enhancement were assessed. MCI patients had significantly larger PSD volume (P = 0.023), a lower peak wash-in rate (P < 0.001), and delayed time to first peak (P = 0.001) compared to controls. In multivariate regression analysis, PSD volume (β = -0.579, 95% CI [-1.072 – -0.086], P = 0.023) and wash-out rate (β = -3.293, 95% CI [-6.351 – -0.235], P = 0.036) were significantly associated with the Mini-Mental State Examination (MMSE) score. Additionally, a lower peak wash-in rate correlated significantly with lower cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA) (P = 0.043). This association highlights a potential link between meningeal lymphatic dysfunction and cognitive decline, suggesting that PSD alterations could reflect early stages of neurodegenerative changes. In conclusion, these PSD structural and functional alterations in MCI patients may serve as early imaging markers, helping in the assessment of disease severity in neurodegenerative conditions such as Alzheimer’s disease. This insight into meningeal lymphatic dysfunction provides a promising direction for early diagnosis and monitoring of cognitive impairment.https://doi.org/10.1038/s41598-025-07909-3Mild cognitive impairmentDementiaMeningeal lymphatic systemMagnetic resonance imagingDynamic contrast-enhanced imaging |
| spellingShingle | Bio Joo Mina Park Song Soo Kim Sung Jun Ahn Han-Kyeol Kim Hanna Cho Chul Hyoung Lyoo Sang Hyun Suh Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment Scientific Reports Mild cognitive impairment Dementia Meningeal lymphatic system Magnetic resonance imaging Dynamic contrast-enhanced imaging |
| title | Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| title_full | Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| title_fullStr | Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| title_full_unstemmed | Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| title_short | Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| title_sort | morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment |
| topic | Mild cognitive impairment Dementia Meningeal lymphatic system Magnetic resonance imaging Dynamic contrast-enhanced imaging |
| url | https://doi.org/10.1038/s41598-025-07909-3 |
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