Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms
Abstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the potential of an engineered oncolytic...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-98588-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849699598653718528 |
|---|---|
| author | Colin H. Quinn Janet R. Julson Michael H. Erwin Hooper R. Markert Larua V. Bownes Jerry E. Stewart Sorina Shirley Karina J. Yoon Jamie M. Aye James M. Markert Elizabeth A. Beierle |
| author_facet | Colin H. Quinn Janet R. Julson Michael H. Erwin Hooper R. Markert Larua V. Bownes Jerry E. Stewart Sorina Shirley Karina J. Yoon Jamie M. Aye James M. Markert Elizabeth A. Beierle |
| author_sort | Colin H. Quinn |
| collection | DOAJ |
| description | Abstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the potential of an engineered oncolytic herpes simplex virus (oHSV), M002, for GEP-NETS. We employed an established long-term passage GEP-NET cell line and a unique, human pediatric patient-derived xenograft GEP-NET line. We found the virus to effectively infect, replicate within, and kill both cell lines in vitro. Similar effects were noted in vivo, with M002 decreasing tumor growth and improving overall survival in mice bearing tumors from both the established cell line and human GEP-NET PDX. Overall, these studies provide an evaluation of an oncolytic HSV in GEP-NETs, highlighting its therapeutic potential and considerations for clinical translation. |
| format | Article |
| id | doaj-art-b54d78e513df41e9be4676ea0d9e7fad |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b54d78e513df41e9be4676ea0d9e7fad2025-08-20T03:18:32ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-98588-7Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasmsColin H. Quinn0Janet R. Julson1Michael H. Erwin2Hooper R. Markert3Larua V. Bownes4Jerry E. Stewart5Sorina Shirley6Karina J. Yoon7Jamie M. Aye8James M. Markert9Elizabeth A. Beierle10Division of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamDepartment of Cell, Developmental and Integrative Biology, University of Alabama at BirminghamDivision of Hematology Oncology, Department of Pediatrics, University of Alabama at BirminghamDepartment of Neurosurgery, University of Alabama at BirminghamDivision of Pediatric Surgery, Department of Surgery, University of Alabama at BirminghamAbstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the potential of an engineered oncolytic herpes simplex virus (oHSV), M002, for GEP-NETS. We employed an established long-term passage GEP-NET cell line and a unique, human pediatric patient-derived xenograft GEP-NET line. We found the virus to effectively infect, replicate within, and kill both cell lines in vitro. Similar effects were noted in vivo, with M002 decreasing tumor growth and improving overall survival in mice bearing tumors from both the established cell line and human GEP-NET PDX. Overall, these studies provide an evaluation of an oncolytic HSV in GEP-NETs, highlighting its therapeutic potential and considerations for clinical translation.https://doi.org/10.1038/s41598-025-98588-7Neuroendocrine tumorsOncolytic virusPatient derived xenograftsTranslational research |
| spellingShingle | Colin H. Quinn Janet R. Julson Michael H. Erwin Hooper R. Markert Larua V. Bownes Jerry E. Stewart Sorina Shirley Karina J. Yoon Jamie M. Aye James M. Markert Elizabeth A. Beierle Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms Scientific Reports Neuroendocrine tumors Oncolytic virus Patient derived xenografts Translational research |
| title | Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| title_full | Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| title_fullStr | Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| title_full_unstemmed | Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| title_short | Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| title_sort | investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms |
| topic | Neuroendocrine tumors Oncolytic virus Patient derived xenografts Translational research |
| url | https://doi.org/10.1038/s41598-025-98588-7 |
| work_keys_str_mv | AT colinhquinn investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT janetrjulson investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT michaelherwin investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT hooperrmarkert investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT laruavbownes investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT jerryestewart investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT sorinashirley investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT karinajyoon investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT jamiemaye investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT jamesmmarkert investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms AT elizabethabeierle investigationofanoncolyticherpessimplexvirusasapotentialtherapeuticagentforgastroenteropancreaticneuroendocrineneoplasms |