Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications
This study aims to develop a robust and reproducible method for fabricating efficient ultrathin antifouling coatings on gold surfaces by leveraging hydroxylation-based surface modifications. An ultrathin antifouling coating of a monoethylene glycol silane derivative, known to reduce fouling by at le...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/15/6/343 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728887425073152 |
|---|---|
| author | Aries Delica Mikhail A. Nazarov Brian De La Franier Michael Thompson |
| author_facet | Aries Delica Mikhail A. Nazarov Brian De La Franier Michael Thompson |
| author_sort | Aries Delica |
| collection | DOAJ |
| description | This study aims to develop a robust and reproducible method for fabricating efficient ultrathin antifouling coatings on gold surfaces by leveraging hydroxylation-based surface modifications. An ultrathin antifouling coating of a monoethylene glycol silane derivative, known to reduce fouling by at least 90% on flat hydroxylated surfaces, was successfully replicated on flat gold (reducing fouling by ~75%) by hydroxylating its surface with β-mercaptoethanol. This tandem coating contains the monoethylene glycol silane layer on top of the β-mercaptoethanol on the gold. Characterization was performed using contact angle goniometry, atomic force microscopy, x-ray photoelectron spectroscopy, and antifouling measurements. The results from these techniques, consistent with the literature, confirmed the successful and reproducible application of the tandem coating. Through heterogeneities, including defects and incomplete coverage, the AFM data revealed distinct visible layers of the tandem coating. The direct application of monoethylene glycol silane onto gold resulted in superior antifouling performance (88% reduction), demonstrating that direct silylation exploits pre-existing oxygen-containing species on the gold surface for a more effective antifouling layer. These findings offer a scalable approach for engineering antifouling coatings on gold substrates, with potential applications in biosensing and implantable device antifouling technologies. |
| format | Article |
| id | doaj-art-b54a538e9c8d42fabce257fbb631293a |
| institution | DOAJ |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-b54a538e9c8d42fabce257fbb631293a2025-08-20T03:09:25ZengMDPI AGBiosensors2079-63742025-05-0115634310.3390/bios15060343Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor ApplicationsAries Delica0Mikhail A. Nazarov1Brian De La Franier2Michael Thompson3Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, CanadaDepartment of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, CanadaDepartment of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, CanadaDepartment of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, CanadaThis study aims to develop a robust and reproducible method for fabricating efficient ultrathin antifouling coatings on gold surfaces by leveraging hydroxylation-based surface modifications. An ultrathin antifouling coating of a monoethylene glycol silane derivative, known to reduce fouling by at least 90% on flat hydroxylated surfaces, was successfully replicated on flat gold (reducing fouling by ~75%) by hydroxylating its surface with β-mercaptoethanol. This tandem coating contains the monoethylene glycol silane layer on top of the β-mercaptoethanol on the gold. Characterization was performed using contact angle goniometry, atomic force microscopy, x-ray photoelectron spectroscopy, and antifouling measurements. The results from these techniques, consistent with the literature, confirmed the successful and reproducible application of the tandem coating. Through heterogeneities, including defects and incomplete coverage, the AFM data revealed distinct visible layers of the tandem coating. The direct application of monoethylene glycol silane onto gold resulted in superior antifouling performance (88% reduction), demonstrating that direct silylation exploits pre-existing oxygen-containing species on the gold surface for a more effective antifouling layer. These findings offer a scalable approach for engineering antifouling coatings on gold substrates, with potential applications in biosensing and implantable device antifouling technologies.https://www.mdpi.com/2079-6374/15/6/343surface-modified goldgold-based biosensoracoustic wave biosensornon-specific adsorptionantifouling coating |
| spellingShingle | Aries Delica Mikhail A. Nazarov Brian De La Franier Michael Thompson Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications Biosensors surface-modified gold gold-based biosensor acoustic wave biosensor non-specific adsorption antifouling coating |
| title | Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications |
| title_full | Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications |
| title_fullStr | Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications |
| title_full_unstemmed | Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications |
| title_short | Antifouling Modification of Gold Surfaces for Acoustic Wave Sensor Applications |
| title_sort | antifouling modification of gold surfaces for acoustic wave sensor applications |
| topic | surface-modified gold gold-based biosensor acoustic wave biosensor non-specific adsorption antifouling coating |
| url | https://www.mdpi.com/2079-6374/15/6/343 |
| work_keys_str_mv | AT ariesdelica antifoulingmodificationofgoldsurfacesforacousticwavesensorapplications AT mikhailanazarov antifoulingmodificationofgoldsurfacesforacousticwavesensorapplications AT briandelafranier antifoulingmodificationofgoldsurfacesforacousticwavesensorapplications AT michaelthompson antifoulingmodificationofgoldsurfacesforacousticwavesensorapplications |