Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram
Objectives: To determine the association between obstructive sleep apnea syndrome (OSAS) severity with the percentages of muscle and fat in males. Methods: A cross-sectional study was performed on 195 eligible males (25–72 years, average age 50). Muscle mass and fat mass were obtained by bioelectric...
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Elsevier
2025-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025015129 |
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| author | Yinghui Gao Libo Zhao Li Fan Weimeng Cai Dong Rui Zhe Zhao Tingyu Nie Tianjiao Li Xin Xue Cong Ma Hongju Xiao Lin Liu |
| author_facet | Yinghui Gao Libo Zhao Li Fan Weimeng Cai Dong Rui Zhe Zhao Tingyu Nie Tianjiao Li Xin Xue Cong Ma Hongju Xiao Lin Liu |
| author_sort | Yinghui Gao |
| collection | DOAJ |
| description | Objectives: To determine the association between obstructive sleep apnea syndrome (OSAS) severity with the percentages of muscle and fat in males. Methods: A cross-sectional study was performed on 195 eligible males (25–72 years, average age 50). Muscle mass and fat mass were obtained by bioelectrical impedance analysis (BIA), and objective indicators associated with OSAS were recorded by polysomnography. The differences in various indicators (such as body composition) between groups with different severities of OSAS were analyzed, and the correlations between variables are also discussed. Results: The correlation analysis demonstrated that the muscle percentage was negatively associated with the waist-to-hip ratio (r = −0.378, P < 0.01), body mass index (BMI) (r = −0.656, P < 0.01), uric acid level (r = 0.152, P < 0.05), hemoglobin level (r = 0.168, P < 0.05), carbon dioxide (CO2) level (r = 0.152, P < 0.05), and apnea-hypopnea index (AHI) (r = −0.230, P < 0.01). In contrast, the fat percentage was positively correlated with the AHI (r = 0.242, P < 0.01) and was negatively correlated with the extracellular water/total body water (ECW/TBW) ratio (r = −0.187, P < 0.01). Even after adjusting for the ECW/TBW, uric acid, hemoglobin, CO2, and other factors, the AHI showed significant independent linear relationships with the muscle percentage [standardized beta coefficient (β) = -0.029, P = 0.047] and fat percentage (β = 0.036, P = 0.005). Conclusions: The severity of OSAS in males was associated with a decreased muscle percentage and an increased fat percentage. |
| format | Article |
| id | doaj-art-b548a96622c044c090cd7cd30f7e4dac |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b548a96622c044c090cd7cd30f7e4dac2025-08-20T02:56:06ZengElsevierHeliyon2405-84402025-03-01116e4313110.1016/j.heliyon.2025.e43131Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogramYinghui Gao0Libo Zhao1Li Fan2Weimeng Cai3Dong Rui4Zhe Zhao5Tingyu Nie6Tianjiao Li7Xin Xue8Cong Ma9Hongju Xiao10Lin Liu11Department of Sleep Medicine, Peking University International Hospital, Beijing, 102206, ChinaCardiology Department of the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, ChinaCardiology Department of the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, ChinaGraduate School, Medical School of Chinese PLA, Beijing, 100853, ChinaGraduate School, Medical School of Chinese PLA, Beijing, 100853, ChinaCardiology Department of the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, ChinaMedicine School, Yan'an University, Yan'an, 716000, ChinaMedicine School, Yan'an University, Yan'an, 716000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Yan'an University, Yan'an, 716000, ChinaHealth Management Institute, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Corresponding author. Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China.Outpatient Department, First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China; Corresponding author.Department of Respiratory and Critical Care Medicine of the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Corresponding author.Objectives: To determine the association between obstructive sleep apnea syndrome (OSAS) severity with the percentages of muscle and fat in males. Methods: A cross-sectional study was performed on 195 eligible males (25–72 years, average age 50). Muscle mass and fat mass were obtained by bioelectrical impedance analysis (BIA), and objective indicators associated with OSAS were recorded by polysomnography. The differences in various indicators (such as body composition) between groups with different severities of OSAS were analyzed, and the correlations between variables are also discussed. Results: The correlation analysis demonstrated that the muscle percentage was negatively associated with the waist-to-hip ratio (r = −0.378, P < 0.01), body mass index (BMI) (r = −0.656, P < 0.01), uric acid level (r = 0.152, P < 0.05), hemoglobin level (r = 0.168, P < 0.05), carbon dioxide (CO2) level (r = 0.152, P < 0.05), and apnea-hypopnea index (AHI) (r = −0.230, P < 0.01). In contrast, the fat percentage was positively correlated with the AHI (r = 0.242, P < 0.01) and was negatively correlated with the extracellular water/total body water (ECW/TBW) ratio (r = −0.187, P < 0.01). Even after adjusting for the ECW/TBW, uric acid, hemoglobin, CO2, and other factors, the AHI showed significant independent linear relationships with the muscle percentage [standardized beta coefficient (β) = -0.029, P = 0.047] and fat percentage (β = 0.036, P = 0.005). Conclusions: The severity of OSAS in males was associated with a decreased muscle percentage and an increased fat percentage.http://www.sciencedirect.com/science/article/pii/S2405844025015129OSASMaleBody compositionBIACorrelationSarcopenia |
| spellingShingle | Yinghui Gao Libo Zhao Li Fan Weimeng Cai Dong Rui Zhe Zhao Tingyu Nie Tianjiao Li Xin Xue Cong Ma Hongju Xiao Lin Liu Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram Heliyon OSAS Male Body composition BIA Correlation Sarcopenia |
| title | Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram |
| title_full | Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram |
| title_fullStr | Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram |
| title_full_unstemmed | Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram |
| title_short | Decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males: Insight from body composition and polysomnogram |
| title_sort | decreased muscle percentage and increased fat percentage associated with obstructive sleep apnea syndrome severity in males insight from body composition and polysomnogram |
| topic | OSAS Male Body composition BIA Correlation Sarcopenia |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025015129 |
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