Acute Coronary Syndrome during the Pandemic New Coronavirus Infection
The experience of managing patients with COVID-19 around the world has shown that, although respiratory symptoms predominate during the manifestation of infection, then many patients can develop serious damage to the cardiovascular system. However, coronary artery disease (CHD) remains the leadin...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2023-03-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2886 |
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| author | O. M. Drapkina A. Ya. Kravchenko A. V. Budnevskiy A. V. Kontsevaya E. S. Ovsyannikov E. S. Drobysheva |
| author_facet | O. M. Drapkina A. Ya. Kravchenko A. V. Budnevskiy A. V. Kontsevaya E. S. Ovsyannikov E. S. Drobysheva |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | The experience of managing patients with COVID-19 around the world has shown that, although respiratory symptoms predominate during the manifestation of infection, then many patients can develop serious damage to the cardiovascular system. However, coronary artery disease (CHD) remains the leading cause of death worldwide. The purpose of the review is to clarify the possible pathogenetic links between COVID-19 and acute coronary syndrome (ACS), taking into account which will help to optimize the management of patients with comorbid pathology. Among the body's responses to SARS-CoV-2 infection, which increase the likelihood of developing ACS, the role of systemic inflammation, the quintessence of which is a "cytokine storm" that can destabilize an atherosclerotic plaque is discussed. Coagulopathy, typical for patients with Covid-19, is based on immunothrombosis, caused by a complex interaction between neutrophilic extracellular traps and von Willebrandt factor in conditions of systemic inflammation. The implementation of a modern strategy for managing patients with ACS, focused on the priority of percutaneous interventions (PCI), during a pandemic is experiencing great difficulties due to the formation of time delays before the start of invasive procedures due to the epidemiological situation. Despite this, the current European, American and Russian recommendations for the management of infected patients with ACS confirm the inviolability of the position of PCI as the first choice for treating patients with ACS and the undesirability of replacing invasive treatment with thrombolysis. |
| format | Article |
| id | doaj-art-b54790fec7b94643b6f12a3802d5bb4b |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-b54790fec7b94643b6f12a3802d5bb4b2025-08-23T10:00:35ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-03-01191657010.20996/1819-6446-2023-01-042097Acute Coronary Syndrome during the Pandemic New Coronavirus InfectionO. M. Drapkina0A. Ya. Kravchenko1A. V. Budnevskiy2A. V. Kontsevaya3E. S. Ovsyannikov4E. S. Drobysheva5National Research Center for Therapy and Preventive MedicineVoronezh State Medical University named after N.N. BurdenkoVoronezh State Medical University named after N.N. BurdenkoNational Research Center for Therapy and Preventive MedicineVoronezh State Medical University named after N.N. BurdenkoVoronezh State Medical University named after N.N. BurdenkoThe experience of managing patients with COVID-19 around the world has shown that, although respiratory symptoms predominate during the manifestation of infection, then many patients can develop serious damage to the cardiovascular system. However, coronary artery disease (CHD) remains the leading cause of death worldwide. The purpose of the review is to clarify the possible pathogenetic links between COVID-19 and acute coronary syndrome (ACS), taking into account which will help to optimize the management of patients with comorbid pathology. Among the body's responses to SARS-CoV-2 infection, which increase the likelihood of developing ACS, the role of systemic inflammation, the quintessence of which is a "cytokine storm" that can destabilize an atherosclerotic plaque is discussed. Coagulopathy, typical for patients with Covid-19, is based on immunothrombosis, caused by a complex interaction between neutrophilic extracellular traps and von Willebrandt factor in conditions of systemic inflammation. The implementation of a modern strategy for managing patients with ACS, focused on the priority of percutaneous interventions (PCI), during a pandemic is experiencing great difficulties due to the formation of time delays before the start of invasive procedures due to the epidemiological situation. Despite this, the current European, American and Russian recommendations for the management of infected patients with ACS confirm the inviolability of the position of PCI as the first choice for treating patients with ACS and the undesirability of replacing invasive treatment with thrombolysis.https://www.rpcardio.online/jour/article/view/2886acute coronary syndromecovid-19inflammationthrombosis |
| spellingShingle | O. M. Drapkina A. Ya. Kravchenko A. V. Budnevskiy A. V. Kontsevaya E. S. Ovsyannikov E. S. Drobysheva Acute Coronary Syndrome during the Pandemic New Coronavirus Infection Рациональная фармакотерапия в кардиологии acute coronary syndrome covid-19 inflammation thrombosis |
| title | Acute Coronary Syndrome during the Pandemic New Coronavirus Infection |
| title_full | Acute Coronary Syndrome during the Pandemic New Coronavirus Infection |
| title_fullStr | Acute Coronary Syndrome during the Pandemic New Coronavirus Infection |
| title_full_unstemmed | Acute Coronary Syndrome during the Pandemic New Coronavirus Infection |
| title_short | Acute Coronary Syndrome during the Pandemic New Coronavirus Infection |
| title_sort | acute coronary syndrome during the pandemic new coronavirus infection |
| topic | acute coronary syndrome covid-19 inflammation thrombosis |
| url | https://www.rpcardio.online/jour/article/view/2886 |
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