Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation

Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation

BackgroundProtocatechualdehyde (PCA), a phenolic compound derived from Salvia miltiorrhiza, exhibits anti-proliferative and antioxidant properties. However, its molecular mechanisms in reducing oxidative stress in diabetic cataract (DC) remain unclear. This study systematically investigated the role...

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Bibliographic Details
Main Authors: Xiao Cheng, Sixuan Zhao, Yucai Chen, Jiawei Wang, Furong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Protocatechualdehyde
Glo1
AGEs/RAGE
oxidative stress
diabetic cataract
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586173/full
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