Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

Abstract We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers. Results were validated through bidirectional two-s...

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Bibliographic Details
Main Authors: Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:AMB Express
Subjects:
Gut microbiota
Pan-cancer
Blood metabolites
Mendelian randomization
Mediation analysis
Metabolic pathway enrichment analysis
Online Access:https://doi.org/10.1186/s13568-025-01866-w
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