L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data
BackgroundIn the post-vaccine era, adjusting living habits and diet structure has become a new way to prevent Human papillomavirus(HPV). Although dietary factors have received much attention, the association of dietary magnesium with HPV infection remains understudied.MethodUsing NHANES cross-sectio...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1594489/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761711363457024 |
|---|---|
| author | Haiwei Chen Xiaotong Chen Yuling Chen Lixin Tang Wen-Jing Shi Yu-Hua Ou |
| author_facet | Haiwei Chen Xiaotong Chen Yuling Chen Lixin Tang Wen-Jing Shi Yu-Hua Ou |
| author_sort | Haiwei Chen |
| collection | DOAJ |
| description | BackgroundIn the post-vaccine era, adjusting living habits and diet structure has become a new way to prevent Human papillomavirus(HPV). Although dietary factors have received much attention, the association of dietary magnesium with HPV infection remains understudied.MethodUsing NHANES cross-sectional data from 2003 to 2016, this study analyzed the relationship between magnesium intake and HPV infection in 7,246 women aged 18–59 years. Weighted logistic regression and subgroup analysis assessed independent links, while curve fitting and threshold analysis defined dose response and saturation.ResultA significant negative correlation was observed between magnesium intake and the risk of HPV infection. After comprehensive adjustment for potential confounding factors, individuals in the highest quartile of magnesium intake exhibited a statistically significant 29.7% reduction in the risk of HPV infection for each additional unit, compared to those in the lowest quartile (CI:0.554–0.894, p = 0.005). Besides, using smooth curve fitting and threshold analysis, we found an L-shaped dose response between magnesium intake and HPV risk. Below 401 mg/day of magnesium, increased intake is inversely correlated with HPV infection risk. Above this threshold, further increases plateaued in risk reduction.ConclusionModerate magnesium intake has a protective effect against HPV infection. Rationally increasing magnesium intake through dietary channels is expected to serve as an effective preventive measure against HPV infection. |
| format | Article |
| id | doaj-art-b5343fcf98a04785bd95fa17fd1d9033 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-b5343fcf98a04785bd95fa17fd1d90332025-08-20T03:05:56ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15944891594489L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 dataHaiwei Chen0Xiaotong Chen1Yuling Chen2Lixin Tang3Wen-Jing Shi4Yu-Hua Ou5Department of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, ChinaDepartment of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, ChinaDepartment of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, ChinaDepartment of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, ChinaDepartment of Gynecology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaDepartment of Gynecology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaBackgroundIn the post-vaccine era, adjusting living habits and diet structure has become a new way to prevent Human papillomavirus(HPV). Although dietary factors have received much attention, the association of dietary magnesium with HPV infection remains understudied.MethodUsing NHANES cross-sectional data from 2003 to 2016, this study analyzed the relationship between magnesium intake and HPV infection in 7,246 women aged 18–59 years. Weighted logistic regression and subgroup analysis assessed independent links, while curve fitting and threshold analysis defined dose response and saturation.ResultA significant negative correlation was observed between magnesium intake and the risk of HPV infection. After comprehensive adjustment for potential confounding factors, individuals in the highest quartile of magnesium intake exhibited a statistically significant 29.7% reduction in the risk of HPV infection for each additional unit, compared to those in the lowest quartile (CI:0.554–0.894, p = 0.005). Besides, using smooth curve fitting and threshold analysis, we found an L-shaped dose response between magnesium intake and HPV risk. Below 401 mg/day of magnesium, increased intake is inversely correlated with HPV infection risk. Above this threshold, further increases plateaued in risk reduction.ConclusionModerate magnesium intake has a protective effect against HPV infection. Rationally increasing magnesium intake through dietary channels is expected to serve as an effective preventive measure against HPV infection.https://www.frontiersin.org/articles/10.3389/fnut.2025.1594489/fullHPV infectionmagnesium intakediet managementnutritional regulationdisease prevention |
| spellingShingle | Haiwei Chen Xiaotong Chen Yuling Chen Lixin Tang Wen-Jing Shi Yu-Hua Ou L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data Frontiers in Nutrition HPV infection magnesium intake diet management nutritional regulation disease prevention |
| title | L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data |
| title_full | L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data |
| title_fullStr | L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data |
| title_full_unstemmed | L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data |
| title_short | L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003–2016 data |
| title_sort | l type association between magnesium intake and human papillomavirus infection in us adult women based on nhanes 2003 2016 data |
| topic | HPV infection magnesium intake diet management nutritional regulation disease prevention |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1594489/full |
| work_keys_str_mv | AT haiweichen ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data AT xiaotongchen ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data AT yulingchen ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data AT lixintang ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data AT wenjingshi ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data AT yuhuaou ltypeassociationbetweenmagnesiumintakeandhumanpapillomavirusinfectioninusadultwomenbasedonnhanes20032016data |