Intercellular communication between FAP+ fibroblasts and SPP1+ macrophages in prostate cancer via multi-omics

Intercellular communication between FAP+ fibroblasts and SPP1+ macrophages in prostate cancer via multi-omics

BackgroundProstate cancer (PCa) presents substantial heterogeneity and unpredictability in its progression. Despite therapeutic advancements, mortality from advanced PCa remains a significant challenge. Understanding the intercellular communication within the tumor microenvironment (TME) is critical...

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Bibliographic Details
Main Authors: Tingting Wu, Xinyu Li, Fei Zheng, Hanchao Liu, Yang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
prostate cancer
tumor microenvironment
cellular crosstalk
single-cell RNA sequencing
spatial transcriptomics
FAP+ fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560998/full
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