Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies
Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal membrane potentials and ion channel activity can drive tumor progression. In breast cancer, ion channel dysfunction and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Receptors |
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| Online Access: | https://www.mdpi.com/2813-2564/4/2/9 |
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| author | Chitaranjan Mahapatra Jineetkumar Gawad Chandrakant Bonde Mahesh B. Palkar |
| author_facet | Chitaranjan Mahapatra Jineetkumar Gawad Chandrakant Bonde Mahesh B. Palkar |
| author_sort | Chitaranjan Mahapatra |
| collection | DOAJ |
| description | Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal membrane potentials and ion channel activity can drive tumor progression. In breast cancer, ion channel dysfunction and neuroreceptor-related pathways play significant roles in the cell cycle, epithelial–mesenchymal transition, angiogenesis, inflammation, the tumor microenvironment, and tumor progression. Neuroreceptors are critical not only in initiating and advancing cancer but also in conferring resistance to treatments. Neuroreceptors also play a key role, with dopamine receptor D2 activation reducing breast tumor growth by 40% in preclinical models, while serotonin signaling has been shown to promote epithelial–mesenchymal transition (EMT), increasing invasiveness. Advances in understanding these biological mechanisms could lead to more cost-effective and less invasive therapeutic strategies to treat tumors. This review explores the expanding evidence connecting bioelectric activity to breast cancer, focusing on neuroreceptor pharmacology as a transformative therapeutic approach. Examining the modulation of bioelectricity through neuroreceptor pharmacology to influence breast cancer progression and integrating these insights into therapeutic development offers a promising path for addressing treatment challenges and improving precision in managing aggressive cancer subtypes. |
| format | Article |
| id | doaj-art-b52fdbcd7f2943c494479a1d41f6dd45 |
| institution | Kabale University |
| issn | 2813-2564 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Receptors |
| spelling | doaj-art-b52fdbcd7f2943c494479a1d41f6dd452025-08-20T03:29:44ZengMDPI AGReceptors2813-25642025-04-0142910.3390/receptors4020009Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic StrategiesChitaranjan Mahapatra0Jineetkumar Gawad1Chandrakant Bonde2Mahesh B. Palkar3NeuroPSI, Paris Saclay University, 91191 Saclay, FranceVIVA Institute of Pharmacy, Virar (East) 401305, IndiaSSR College of Pharmacy, Silvassa 396230, IndiaShobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS University, Vile Parle (W), Mumbai 400056, IndiaBioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal membrane potentials and ion channel activity can drive tumor progression. In breast cancer, ion channel dysfunction and neuroreceptor-related pathways play significant roles in the cell cycle, epithelial–mesenchymal transition, angiogenesis, inflammation, the tumor microenvironment, and tumor progression. Neuroreceptors are critical not only in initiating and advancing cancer but also in conferring resistance to treatments. Neuroreceptors also play a key role, with dopamine receptor D2 activation reducing breast tumor growth by 40% in preclinical models, while serotonin signaling has been shown to promote epithelial–mesenchymal transition (EMT), increasing invasiveness. Advances in understanding these biological mechanisms could lead to more cost-effective and less invasive therapeutic strategies to treat tumors. This review explores the expanding evidence connecting bioelectric activity to breast cancer, focusing on neuroreceptor pharmacology as a transformative therapeutic approach. Examining the modulation of bioelectricity through neuroreceptor pharmacology to influence breast cancer progression and integrating these insights into therapeutic development offers a promising path for addressing treatment challenges and improving precision in managing aggressive cancer subtypes.https://www.mdpi.com/2813-2564/4/2/9bioelectric signalingneuroreceptor pharmacologybreast cancertherapeutic strategies |
| spellingShingle | Chitaranjan Mahapatra Jineetkumar Gawad Chandrakant Bonde Mahesh B. Palkar Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies Receptors bioelectric signaling neuroreceptor pharmacology breast cancer therapeutic strategies |
| title | Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies |
| title_full | Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies |
| title_fullStr | Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies |
| title_full_unstemmed | Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies |
| title_short | Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies |
| title_sort | bioelectric membrane potential and breast cancer advances in neuroreceptor pharmacology for targeted therapeutic strategies |
| topic | bioelectric signaling neuroreceptor pharmacology breast cancer therapeutic strategies |
| url | https://www.mdpi.com/2813-2564/4/2/9 |
| work_keys_str_mv | AT chitaranjanmahapatra bioelectricmembranepotentialandbreastcanceradvancesinneuroreceptorpharmacologyfortargetedtherapeuticstrategies AT jineetkumargawad bioelectricmembranepotentialandbreastcanceradvancesinneuroreceptorpharmacologyfortargetedtherapeuticstrategies AT chandrakantbonde bioelectricmembranepotentialandbreastcanceradvancesinneuroreceptorpharmacologyfortargetedtherapeuticstrategies AT maheshbpalkar bioelectricmembranepotentialandbreastcanceradvancesinneuroreceptorpharmacologyfortargetedtherapeuticstrategies |