Application of Spatial Transcriptomics in Digestive System Tumors
In the field of digestive system tumor research, spatial transcriptomics technologies are used to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the tumor microenvironment (TME) and the inter-cellular interactions within it by revealing gene expression in tum...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589004210438144 |
|---|---|
| author | Bowen Huang Yingjia Chen Shuqiang Yuan |
| author_facet | Bowen Huang Yingjia Chen Shuqiang Yuan |
| author_sort | Bowen Huang |
| collection | DOAJ |
| description | In the field of digestive system tumor research, spatial transcriptomics technologies are used to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the tumor microenvironment (TME) and the inter-cellular interactions within it by revealing gene expression in tumors. These technologies are also instrumental in the diagnosis, prognosis, and treatment of digestive system tumors. This review provides a concise introduction to spatial transcriptomics and summarizes recent advances, application prospects, and technical challenges of these technologies in digestive system tumor research. This review also discusses the importance of combining spatial transcriptomics with single-cell RNA sequencing (scRNA-seq), artificial intelligence, and machine learning in digestive system cancer research. |
| format | Article |
| id | doaj-art-b52be6e261894e54b37845e532b76f86 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-b52be6e261894e54b37845e532b76f862025-01-24T13:24:53ZengMDPI AGBiomolecules2218-273X2024-12-011512110.3390/biom15010021Application of Spatial Transcriptomics in Digestive System TumorsBowen Huang0Yingjia Chen1Shuqiang Yuan2Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, ChinaHealth Science Center, Peking University, Beijing 100191, ChinaDepartment of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, ChinaIn the field of digestive system tumor research, spatial transcriptomics technologies are used to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the tumor microenvironment (TME) and the inter-cellular interactions within it by revealing gene expression in tumors. These technologies are also instrumental in the diagnosis, prognosis, and treatment of digestive system tumors. This review provides a concise introduction to spatial transcriptomics and summarizes recent advances, application prospects, and technical challenges of these technologies in digestive system tumor research. This review also discusses the importance of combining spatial transcriptomics with single-cell RNA sequencing (scRNA-seq), artificial intelligence, and machine learning in digestive system cancer research.https://www.mdpi.com/2218-273X/15/1/21spatial transcriptomicstumor microenvironmentspatial heterogeneitydigestive system tumorsinter-cellular interaction |
| spellingShingle | Bowen Huang Yingjia Chen Shuqiang Yuan Application of Spatial Transcriptomics in Digestive System Tumors Biomolecules spatial transcriptomics tumor microenvironment spatial heterogeneity digestive system tumors inter-cellular interaction |
| title | Application of Spatial Transcriptomics in Digestive System Tumors |
| title_full | Application of Spatial Transcriptomics in Digestive System Tumors |
| title_fullStr | Application of Spatial Transcriptomics in Digestive System Tumors |
| title_full_unstemmed | Application of Spatial Transcriptomics in Digestive System Tumors |
| title_short | Application of Spatial Transcriptomics in Digestive System Tumors |
| title_sort | application of spatial transcriptomics in digestive system tumors |
| topic | spatial transcriptomics tumor microenvironment spatial heterogeneity digestive system tumors inter-cellular interaction |
| url | https://www.mdpi.com/2218-273X/15/1/21 |
| work_keys_str_mv | AT bowenhuang applicationofspatialtranscriptomicsindigestivesystemtumors AT yingjiachen applicationofspatialtranscriptomicsindigestivesystemtumors AT shuqiangyuan applicationofspatialtranscriptomicsindigestivesystemtumors |