Age at type 1 diabetes onset does not influence attained brain volume
Abstract Introduction Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis. Methods Examining brain MRI scans of middle-aged people with type 1 diabetes, we rela...
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| Language: | English |
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BMC
2025-02-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-01868-6 |
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| author | Tor-björn Claesson Stefan Mutter Jukka Putaala Eero Salli Daniel Gordin Per-Henrik Groop Juha Martola Lena M. Thorn |
| author_facet | Tor-björn Claesson Stefan Mutter Jukka Putaala Eero Salli Daniel Gordin Per-Henrik Groop Juha Martola Lena M. Thorn |
| author_sort | Tor-björn Claesson |
| collection | DOAJ |
| description | Abstract Introduction Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis. Methods Examining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a subset of 113 (63%) participants, using fractional polynomial regression models. Of the participants, 118 (67%) had been diagnosed with diabetes before 18 years of age. Results Of our participants, 54% were women, the median age 40.0 (IQR 33.2–45.0) years and the range of age at diabetes onset was 1.2–39.0 years. We found no association between age at diabetes onset and intracranial volume (p = 0.85), cerebral white (p = 0.10), or gray matter volumes (p = 0.12). Further, correlations between age at diabetes onset and the measured brain volumes were poor in analyses stratified for sex (all correlation coefficients ρ ≤ 0.16). Conclusions We found no association between age at diabetes onset and attained intracranial volume or gray or white matter volumes, indicating that type 1 diabetes may not have a clinically significant influence on brain growth. |
| format | Article |
| id | doaj-art-b527e7b37d034e8a9d36ede9aca69260 |
| institution | OA Journals |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-b527e7b37d034e8a9d36ede9aca692602025-08-20T02:15:00ZengBMCBMC Endocrine Disorders1472-68232025-02-012511710.1186/s12902-025-01868-6Age at type 1 diabetes onset does not influence attained brain volumeTor-björn Claesson0Stefan Mutter1Jukka Putaala2Eero Salli3Daniel Gordin4Per-Henrik Groop5Juha Martola6Lena M. Thorn7Department of Radiology, University of Helsinki and Helsinki University HospitalFolkhälsan Research CentreDepartment of Neurology, University of Helsinki and Helsinki University HospitalDepartment of Radiology, University of Helsinki and Helsinki University HospitalDepartment of Nephrology, University of Helsinki and Helsinki University HospitalFolkhälsan Research CentreDepartment of Radiology, University of Helsinki and Helsinki University HospitalFolkhälsan Research CentreAbstract Introduction Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis. Methods Examining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a subset of 113 (63%) participants, using fractional polynomial regression models. Of the participants, 118 (67%) had been diagnosed with diabetes before 18 years of age. Results Of our participants, 54% were women, the median age 40.0 (IQR 33.2–45.0) years and the range of age at diabetes onset was 1.2–39.0 years. We found no association between age at diabetes onset and intracranial volume (p = 0.85), cerebral white (p = 0.10), or gray matter volumes (p = 0.12). Further, correlations between age at diabetes onset and the measured brain volumes were poor in analyses stratified for sex (all correlation coefficients ρ ≤ 0.16). Conclusions We found no association between age at diabetes onset and attained intracranial volume or gray or white matter volumes, indicating that type 1 diabetes may not have a clinically significant influence on brain growth.https://doi.org/10.1186/s12902-025-01868-6Age of onsetBrainGray matterWhite matterMagnetic resonance imagingDiabetes mellitus, type 1 |
| spellingShingle | Tor-björn Claesson Stefan Mutter Jukka Putaala Eero Salli Daniel Gordin Per-Henrik Groop Juha Martola Lena M. Thorn Age at type 1 diabetes onset does not influence attained brain volume BMC Endocrine Disorders Age of onset Brain Gray matter White matter Magnetic resonance imaging Diabetes mellitus, type 1 |
| title | Age at type 1 diabetes onset does not influence attained brain volume |
| title_full | Age at type 1 diabetes onset does not influence attained brain volume |
| title_fullStr | Age at type 1 diabetes onset does not influence attained brain volume |
| title_full_unstemmed | Age at type 1 diabetes onset does not influence attained brain volume |
| title_short | Age at type 1 diabetes onset does not influence attained brain volume |
| title_sort | age at type 1 diabetes onset does not influence attained brain volume |
| topic | Age of onset Brain Gray matter White matter Magnetic resonance imaging Diabetes mellitus, type 1 |
| url | https://doi.org/10.1186/s12902-025-01868-6 |
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