Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
Abstract The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and photodynamic treatment for cancer. Howev...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22594-2 |
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| author | Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang |
| author_facet | Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang |
| author_sort | Lei Jiang |
| collection | DOAJ |
| description | Abstract The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and photodynamic treatment for cancer. However, targeted delivery of therapeutics to mitochondria remains a great challenge due to their location in the sub-cellular compartment and complexity of the intracellular environment. Herein, we report a class of the mitochondrion-targeted liposomal delivery platform consisting of a guanidinium-based dendritic peptide moiety mimicking mitochondrion protein transmembrane signaling to exert mitochondrion-targeted delivery with pH sensitive and charge-reversible functions to enhance tumor accumulation and cell penetration. Compared to the current triphenylphosphonium (TPP)-based mitochondrion targeting system, this dendritic lipopeptide (DLP) liposomal delivery platform exhibits about 3.7-fold higher mitochondrion-targeted delivery efficacy. Complete tumor eradication is demonstrated in mice bearing 4T1 mammary tumors after combined photothermal and photodynamic therapies delivered by the reported DLP platform. |
| format | Article |
| id | doaj-art-b523e89cd2e14554af8523e7a2b39849 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b523e89cd2e14554af8523e7a2b398492025-08-20T03:27:18ZengNature PortfolioNature Communications2041-17232021-04-0112111210.1038/s41467-021-22594-2Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular deliveryLei Jiang0Sensen Zhou1Xiaoke Zhang2Cheng Li3Shilu Ji4Hui Mao5Xiqun Jiang6MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityMOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityMOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityMOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityMOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityDepartment of Radiology and Imaging Sciences, Emory UniversityMOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing UniversityAbstract The mitochondrion is an important sub-cellular organelle responsible for the cellular energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen species, the mitochondrion is an appropriate target for photothermal and photodynamic treatment for cancer. However, targeted delivery of therapeutics to mitochondria remains a great challenge due to their location in the sub-cellular compartment and complexity of the intracellular environment. Herein, we report a class of the mitochondrion-targeted liposomal delivery platform consisting of a guanidinium-based dendritic peptide moiety mimicking mitochondrion protein transmembrane signaling to exert mitochondrion-targeted delivery with pH sensitive and charge-reversible functions to enhance tumor accumulation and cell penetration. Compared to the current triphenylphosphonium (TPP)-based mitochondrion targeting system, this dendritic lipopeptide (DLP) liposomal delivery platform exhibits about 3.7-fold higher mitochondrion-targeted delivery efficacy. Complete tumor eradication is demonstrated in mice bearing 4T1 mammary tumors after combined photothermal and photodynamic therapies delivered by the reported DLP platform.https://doi.org/10.1038/s41467-021-22594-2 |
| spellingShingle | Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery Nature Communications |
| title | Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery |
| title_full | Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery |
| title_fullStr | Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery |
| title_full_unstemmed | Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery |
| title_short | Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery |
| title_sort | mitochondrion specific dendritic lipopeptide liposomes for targeted sub cellular delivery |
| url | https://doi.org/10.1038/s41467-021-22594-2 |
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