Pluripotency Factors on Their Lineage Move
Pluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers. Regulatory networks of maintaining pluripotency have been described in great detail and, similarly, there is great knowledge on key players that r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6838253 |
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| author | Clair E. Weidgang Thomas Seufferlein Alexander Kleger Martin Mueller |
| author_facet | Clair E. Weidgang Thomas Seufferlein Alexander Kleger Martin Mueller |
| author_sort | Clair E. Weidgang |
| collection | DOAJ |
| description | Pluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers. Regulatory networks of maintaining pluripotency have been described in great detail and, similarly, there is great knowledge on key players that regulate their differentiation. Interestingly, pluripotency has various shades with distinct developmental potential, an observation that coined the term of a ground state of pluripotency. A precise interplay of signalling axes regulates ground state conditions and acts in concert with a combination of key transcription factors. The balance between these transcription factors greatly influences the integrity of the pluripotency network and latest research suggests that minute changes in their expression can strengthen but also collapse the network. Moreover, recent studies reveal different facets of these core factors in balancing a controlled and directed exit from pluripotency. Thereby, subsets of pluripotency-maintaining factors have been shown to adopt new roles during lineage specification and have been globally defined towards neuroectodermal and mesendodermal sets of embryonic stem cell genes. However, detailed underlying insights into how these transcription factors orchestrate cell fate decisions remain largely elusive. Our group and others unravelled complex interactions in the regulation of this controlled exit. Herein, we summarise recent findings and discuss the potential mechanisms involved. |
| format | Article |
| id | doaj-art-b520583959e04c8abb617ec9f50bed2c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b520583959e04c8abb617ec9f50bed2c2025-02-03T05:44:26ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/68382536838253Pluripotency Factors on Their Lineage MoveClair E. Weidgang0Thomas Seufferlein1Alexander Kleger2Martin Mueller3Department of Internal Medicine I, Ulm University Hospital, 89069 Ulm, GermanyDepartment of Internal Medicine I, Ulm University Hospital, 89069 Ulm, GermanyDepartment of Internal Medicine I, Ulm University Hospital, 89069 Ulm, GermanyDepartment of Internal Medicine I, Ulm University Hospital, 89069 Ulm, GermanyPluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers. Regulatory networks of maintaining pluripotency have been described in great detail and, similarly, there is great knowledge on key players that regulate their differentiation. Interestingly, pluripotency has various shades with distinct developmental potential, an observation that coined the term of a ground state of pluripotency. A precise interplay of signalling axes regulates ground state conditions and acts in concert with a combination of key transcription factors. The balance between these transcription factors greatly influences the integrity of the pluripotency network and latest research suggests that minute changes in their expression can strengthen but also collapse the network. Moreover, recent studies reveal different facets of these core factors in balancing a controlled and directed exit from pluripotency. Thereby, subsets of pluripotency-maintaining factors have been shown to adopt new roles during lineage specification and have been globally defined towards neuroectodermal and mesendodermal sets of embryonic stem cell genes. However, detailed underlying insights into how these transcription factors orchestrate cell fate decisions remain largely elusive. Our group and others unravelled complex interactions in the regulation of this controlled exit. Herein, we summarise recent findings and discuss the potential mechanisms involved.http://dx.doi.org/10.1155/2016/6838253 |
| spellingShingle | Clair E. Weidgang Thomas Seufferlein Alexander Kleger Martin Mueller Pluripotency Factors on Their Lineage Move Stem Cells International |
| title | Pluripotency Factors on Their Lineage Move |
| title_full | Pluripotency Factors on Their Lineage Move |
| title_fullStr | Pluripotency Factors on Their Lineage Move |
| title_full_unstemmed | Pluripotency Factors on Their Lineage Move |
| title_short | Pluripotency Factors on Their Lineage Move |
| title_sort | pluripotency factors on their lineage move |
| url | http://dx.doi.org/10.1155/2016/6838253 |
| work_keys_str_mv | AT claireweidgang pluripotencyfactorsontheirlineagemove AT thomasseufferlein pluripotencyfactorsontheirlineagemove AT alexanderkleger pluripotencyfactorsontheirlineagemove AT martinmueller pluripotencyfactorsontheirlineagemove |