Combined treatment with mesenchymal stem cells and therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a phase 1/2 randomized trial

Combined treatment with mesenchymal stem cells and therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a phase 1/2 randomized trial

Abstract Neonatal hypoxic ischemic encephalopathy (nHIE) is a serious disease that causes severe and chronic neurological damage. Hypothermia therapy improves patients’ outcomes albeit with some limitations, but combining it with treatment with cord blood cells (analogous to mesenchymal stem cells [...

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Main Authors: Kazuko Wada, Akihito Takeuchi, Yoshinori Katayama, Natsuki Ohkawa, Masato Kantake, Kazumichi Fujioka, Toshiya Nishikubo, Yutaka Yamamoto, Yasumasa Yamada, Seiji Yoshimoto, Kiyoaki Sumi, Tomoaki Ioroi, Takeo Mure, Norihisa Wada, Yukimichi Nakano, Naoko Takasao, Kenji Tada, Tatsuyoshi Yamamoto, Hideaki Hirai, Yuji Sato, Hideyuki Ide, Satoshi Kusuda
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-98504-z
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