Multiparametric Magnetic Resonance Imaging Findings of the Pancreas: A Comparison in Patients with Type 1 and 2 Diabetes
Background/Objectives: Diabetes-related pancreatic changes on MRI remain unclear. Thus, we evaluated the pancreatic changes on MRI in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D) using multiparametric MRI. Methods: This prospective study involved patients with T1D or T2D who un...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
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| Series: | Tomography |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2379-139X/11/2/16 |
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| Summary: | Background/Objectives: Diabetes-related pancreatic changes on MRI remain unclear. Thus, we evaluated the pancreatic changes on MRI in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D) using multiparametric MRI. Methods: This prospective study involved patients with T1D or T2D who underwent upper abdominal 3-T MRI. Additionally, patients without impaired glucose metabolism were retrospectively included as a control. The imaging data included pancreatic anteroposterior (AP) diameter, pancreas-to-muscle signal intensity ratio (SIR) on fat-suppressed T1-weighted image (FS-T1WI), apparent diffusion coefficient (ADC) value, T1 value on T1 map, proton density fat fraction (PDFF), and mean secretion grade of pancreatic juice flow on cine-dynamic magnetic resonance cholangiopancreatography (MRCP). The MR measurements were compared using one-way analysis of variance and the Kruskal–Wallis test. Results: Sixty-one patients with T1D (<i>n</i> = 7) or T2D (<i>n</i> = 54) and 21 control patients were evaluated. The pancreatic AP diameters were significantly smaller in patients with T1D than in patients with T2D (<i>p</i> < 0.05). The average SIR on FS-T1WI was significantly lower in patients with T1D than in controls (<i>p</i> < 0.001). The average ADC and T1 values of the pancreas were significantly higher in patients with T1D than in patients with T2D (<i>p</i> < 0.01) and controls (<i>p</i> < 0.05). The mean secretion grade of pancreatic juice flow was significantly lower in patients with T1D than in controls (<i>p</i> = 0.019). The average PDFF of the pancreas was significantly higher in patients with T2D than in controls (<i>p</i> = 0.029). Conclusions: Patients with T1D had reduced pancreas size, increased pancreatic T1 and ADC values, and decreased pancreatic juice flow on cine-dynamic MRCP, whereas patients with T2D had increased pancreatic fat content. |
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| ISSN: | 2379-1381 2379-139X |