LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation
ABSTRACT LINC00922, a long non‐coding RNA (lncRNA) located at chromosome 16q21, has emerged as a crucial regulatory molecule in cancer progression, chemotherapy resistance, and immune modulation. This lncRNA is predominantly localized in the cytoplasm, with limited expression in the nucleus and exos...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Medicine Advances |
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| Online Access: | https://doi.org/10.1002/med4.70018 |
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| author | Jiahua Si Chenhao Liang Xueting Zhang Hening Xu Xinming Su Luqing Liu Ruyi Yuan Yuemin Ding Shiwei Duan |
| author_facet | Jiahua Si Chenhao Liang Xueting Zhang Hening Xu Xinming Su Luqing Liu Ruyi Yuan Yuemin Ding Shiwei Duan |
| author_sort | Jiahua Si |
| collection | DOAJ |
| description | ABSTRACT LINC00922, a long non‐coding RNA (lncRNA) located at chromosome 16q21, has emerged as a crucial regulatory molecule in cancer progression, chemotherapy resistance, and immune modulation. This lncRNA is predominantly localized in the cytoplasm, with limited expression in the nucleus and exosomes. Elevated LINC00922 expression levels are associated with poor patient prognosis across various cancer types. LINC00922 can regulate cancer cell behavior through complex gene regulatory networks, including interactions with several key signaling pathways, such as the Wnt, telomerase, and immune response pathways. Importantly, LINC00922 participates in multiple competing endogenous RNA axes, influencing the expression patterns of target microRNAs like miR‐424‐5p and miR‐874‐3p, which in turn regulate important cancer‐related genes, such as TFAP2C and GDPD5 contributing to chemotherapy resistance. LINC00922 can also promote immune cell infiltration in tumors, with its high expression levels correlating with extensive immune cell presence, suggesting potential for cancer immunotherapy. Despite these promising findings, the upstream regulatory factors of LINC00922 remain poorly understood and further research is needed to fully uncover its clinical potential. In this review, we highlight the multifaceted roles of LINC00922 in cancer, emphasizing the need for future studies to explore its potential as a therapeutic target and diagnostic biomarker. |
| format | Article |
| id | doaj-art-b5170b0c0a59423bb874ec99bdd7afb4 |
| institution | DOAJ |
| issn | 2834-4391 2834-4405 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Medicine Advances |
| spelling | doaj-art-b5170b0c0a59423bb874ec99bdd7afb42025-08-20T03:15:44ZengWileyMedicine Advances2834-43912834-44052025-06-0132657910.1002/med4.70018LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA RegulationJiahua Si0Chenhao Liang1Xueting Zhang2Hening Xu3Xinming Su4Luqing Liu5Ruyi Yuan6Yuemin Ding7Shiwei Duan8Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Hangzhou Zhejiang ChinaABSTRACT LINC00922, a long non‐coding RNA (lncRNA) located at chromosome 16q21, has emerged as a crucial regulatory molecule in cancer progression, chemotherapy resistance, and immune modulation. This lncRNA is predominantly localized in the cytoplasm, with limited expression in the nucleus and exosomes. Elevated LINC00922 expression levels are associated with poor patient prognosis across various cancer types. LINC00922 can regulate cancer cell behavior through complex gene regulatory networks, including interactions with several key signaling pathways, such as the Wnt, telomerase, and immune response pathways. Importantly, LINC00922 participates in multiple competing endogenous RNA axes, influencing the expression patterns of target microRNAs like miR‐424‐5p and miR‐874‐3p, which in turn regulate important cancer‐related genes, such as TFAP2C and GDPD5 contributing to chemotherapy resistance. LINC00922 can also promote immune cell infiltration in tumors, with its high expression levels correlating with extensive immune cell presence, suggesting potential for cancer immunotherapy. Despite these promising findings, the upstream regulatory factors of LINC00922 remain poorly understood and further research is needed to fully uncover its clinical potential. In this review, we highlight the multifaceted roles of LINC00922 in cancer, emphasizing the need for future studies to explore its potential as a therapeutic target and diagnostic biomarker.https://doi.org/10.1002/med4.70018cancer progressionchemotherapy resistanceimmune modulationLINC00922long noncoding RNAmiRNA regulation |
| spellingShingle | Jiahua Si Chenhao Liang Xueting Zhang Hening Xu Xinming Su Luqing Liu Ruyi Yuan Yuemin Ding Shiwei Duan LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation Medicine Advances cancer progression chemotherapy resistance immune modulation LINC00922 long noncoding RNA miRNA regulation |
| title | LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation |
| title_full | LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation |
| title_fullStr | LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation |
| title_full_unstemmed | LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation |
| title_short | LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation |
| title_sort | linc00922 a critical oncogenic long non coding rna involved in cancer progression chemotherapy resistance and microrna regulation |
| topic | cancer progression chemotherapy resistance immune modulation LINC00922 long noncoding RNA miRNA regulation |
| url | https://doi.org/10.1002/med4.70018 |
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