Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease
[Objectives] To compare different intestinal contrast agents in multislice computed tomography enterography (MSCTE) examination for Crohn’s disease (CD). [Methods] Sixty patients requiring MSCTE examination for a diagnosis of CD at Beijing Anorectal Hospital—Beijing Erlong Road Hospital from January...
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Editorial Office of Journal of Colorectal & Anal Surgery
2022-12-01
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| Series: | 结直肠肛门外科 |
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| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=331&cateName=2022%E5%B9%B4%20%E7%AC%AC28%E5%8D%B7%20%E7%AC%AC6%E6%9C%9F |
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| author | Li Jiayan Zhang Junmei Cao Di |
| author_facet | Li Jiayan Zhang Junmei Cao Di |
| author_sort | Li Jiayan |
| collection | DOAJ |
| description | [Objectives] To compare different intestinal contrast agents in multislice computed tomography enterography (MSCTE) examination for Crohn’s disease (CD). [Methods] Sixty patients requiring MSCTE examination for a diagnosis of CD at Beijing Anorectal Hospital—Beijing Erlong Road Hospital from January 2018 to December 2019 were recruited and randomly assigned to receive lactulose (n=30) or mannitol (n=30) as the contrast agents. The followings were compared between the two groups: imaging effect evaluated using the cross-sectional diameter of the small intestinal canal (duodenum, jejunum, and ileum), degree of small intestinal dilatation, and clarity of display of intestinal wall structures, distinctive imaging characteristics of MSCTE examination in patients with CD, adverse effects (AE), and score of acceptance of intestinal contrast agents. [Results] The two groups did not differ significantly in terms of the cross-sectional diameter of the small intestinal canal (duodenum, jejunum, and ileum), degree of small intestinal dilatation, clarity of display of intestinal wall structures, and distinctive imaging characteristics of MSCTE examination of CD (P>0.05). Within 24 hours of oral administration, in the lactulose group, six patients experienced one AE, two patients experienced two AEs, and no patient experienced three AEs; in the mannitol group, six patients experienced one AE, two patients experienced two AEs, and two patients experienced three AEs. No patient had AEs such as electrolyte disturbance, dehydration, and palpitations. The overall AEs rate was significantly lower, and the score of acceptance of intestinal contrast agent was significantly higher in the lactulose group than in the mannitol group (P<0.05). [Conclusion] Compared with traditional contrast agent of mannitol, lactulose can achieve comparable effect with fewer AEs. Its other advantages include better taste, better acceptance, and the potential to protect intestinal tract; therefore, it may be more suitable for CD patients. |
| format | Article |
| id | doaj-art-b50efddfb3a7464787dff1f0ce41bfed |
| institution | Kabale University |
| issn | 1674-0491 |
| language | zho |
| publishDate | 2022-12-01 |
| publisher | Editorial Office of Journal of Colorectal & Anal Surgery |
| record_format | Article |
| series | 结直肠肛门外科 |
| spelling | doaj-art-b50efddfb3a7464787dff1f0ce41bfed2025-08-20T03:49:41ZzhoEditorial Office of Journal of Colorectal & Anal Surgery结直肠肛门外科1674-04912022-12-0128659860210.19668/j.cnki.issn1674-0491.2022.06.015Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s diseaseLi Jiayan0Zhang Junmei1Cao Di2Department of Radiology, Beijing Anorectal Hospital—Beijing Erlong Road Hospital, Beijing 100120, ChinaDepartment of Internal Medicine, Beijing Anorectal Hospital—Beijing Erlong Road Hospital, Beijing 100120, ChinaDepartment of Surgery, Beijing Anorectal Hospital—Beijing Erlong Road Hospital, Beijing 100120, China[Objectives] To compare different intestinal contrast agents in multislice computed tomography enterography (MSCTE) examination for Crohn’s disease (CD). [Methods] Sixty patients requiring MSCTE examination for a diagnosis of CD at Beijing Anorectal Hospital—Beijing Erlong Road Hospital from January 2018 to December 2019 were recruited and randomly assigned to receive lactulose (n=30) or mannitol (n=30) as the contrast agents. The followings were compared between the two groups: imaging effect evaluated using the cross-sectional diameter of the small intestinal canal (duodenum, jejunum, and ileum), degree of small intestinal dilatation, and clarity of display of intestinal wall structures, distinctive imaging characteristics of MSCTE examination in patients with CD, adverse effects (AE), and score of acceptance of intestinal contrast agents. [Results] The two groups did not differ significantly in terms of the cross-sectional diameter of the small intestinal canal (duodenum, jejunum, and ileum), degree of small intestinal dilatation, clarity of display of intestinal wall structures, and distinctive imaging characteristics of MSCTE examination of CD (P>0.05). Within 24 hours of oral administration, in the lactulose group, six patients experienced one AE, two patients experienced two AEs, and no patient experienced three AEs; in the mannitol group, six patients experienced one AE, two patients experienced two AEs, and two patients experienced three AEs. No patient had AEs such as electrolyte disturbance, dehydration, and palpitations. The overall AEs rate was significantly lower, and the score of acceptance of intestinal contrast agent was significantly higher in the lactulose group than in the mannitol group (P<0.05). [Conclusion] Compared with traditional contrast agent of mannitol, lactulose can achieve comparable effect with fewer AEs. Its other advantages include better taste, better acceptance, and the potential to protect intestinal tract; therefore, it may be more suitable for CD patients.https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=331&cateName=2022%E5%B9%B4%20%E7%AC%AC28%E5%8D%B7%20%E7%AC%AC6%E6%9C%9Fcrohn’s diseaseintestinal contrast agentsmultislice computed tomography enterographyeffect |
| spellingShingle | Li Jiayan Zhang Junmei Cao Di Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease 结直肠肛门外科 crohn’s disease intestinal contrast agents multislice computed tomography enterography effect |
| title | Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease |
| title_full | Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease |
| title_fullStr | Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease |
| title_full_unstemmed | Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease |
| title_short | Comparing different intestinal contrast agents in multislice computed tomography enterography examination for Crohn’s disease |
| title_sort | comparing different intestinal contrast agents in multislice computed tomography enterography examination for crohn s disease |
| topic | crohn’s disease intestinal contrast agents multislice computed tomography enterography effect |
| url | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=331&cateName=2022%E5%B9%B4%20%E7%AC%AC28%E5%8D%B7%20%E7%AC%AC6%E6%9C%9F |
| work_keys_str_mv | AT lijiayan comparingdifferentintestinalcontrastagentsinmultislicecomputedtomographyenterographyexaminationforcrohnsdisease AT zhangjunmei comparingdifferentintestinalcontrastagentsinmultislicecomputedtomographyenterographyexaminationforcrohnsdisease AT caodi comparingdifferentintestinalcontrastagentsinmultislicecomputedtomographyenterographyexaminationforcrohnsdisease |