Adult height in Turkish patients with Turner syndrome without growth hormone treatment
Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS. On...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2008-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2460 |
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| author | Abdullah Bereket Sule Can Ebru Ozerkan Mahmut Coker Sükran Darcan Behzat Ozkan Zerrin Orbak Sitki Oztaş Sükrü Palandüz Ilhan Sezgin Emre Atabek Ibrahim Erkul Metin Yildiz Pinar Işgüven Serap Turan Nursel Elçioğlu Seniha Hacihanefioğlu Nihal Memioğlu Firdevs Baş Rüveyde Bundak Feyza Darendeliler Hülya Günöz Nurçin Saka Oya Ercan Ilknur Arslanoğlu Gürbüz Erdoğan |
| author_facet | Abdullah Bereket Sule Can Ebru Ozerkan Mahmut Coker Sükran Darcan Behzat Ozkan Zerrin Orbak Sitki Oztaş Sükrü Palandüz Ilhan Sezgin Emre Atabek Ibrahim Erkul Metin Yildiz Pinar Işgüven Serap Turan Nursel Elçioğlu Seniha Hacihanefioğlu Nihal Memioğlu Firdevs Baş Rüveyde Bundak Feyza Darendeliler Hülya Günöz Nurçin Saka Oya Ercan Ilknur Arslanoğlu Gürbüz Erdoğan |
| author_sort | Abdullah Bereket |
| collection | DOAJ |
| description |
Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS. One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age > 15 years) without receiving GH treatment were included in the study. The average AH was found to be 141.6 +/- 7.0 cm at the age of 22.9 +/- 6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3 +/- 1.3 year. Karyotype distribution of the patients was 45X (43%), 45X/46XX (16%), 45X/46Xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4 +/- 6.9 cm vs 140.9 +/- 7.1 cm, respectively). Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS.
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| format | Article |
| id | doaj-art-b508ec0b120f46aba4e6201ce227a114 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2008-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-b508ec0b120f46aba4e6201ce227a1142025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212008-10-01505Adult height in Turkish patients with Turner syndrome without growth hormone treatmentAbdullah Bereket0Sule CanEbru OzerkanMahmut CokerSükran DarcanBehzat OzkanZerrin OrbakSitki OztaşSükrü PalandüzIlhan SezginEmre AtabekIbrahim ErkulMetin YildizPinar IşgüvenSerap TuranNursel ElçioğluSeniha HacihanefioğluNihal MemioğluFirdevs BaşRüveyde BundakFeyza DarendelilerHülya GünözNurçin SakaOya ErcanIlknur ArslanoğluGürbüz ErdoğanDepartment of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey. Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS. One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age > 15 years) without receiving GH treatment were included in the study. The average AH was found to be 141.6 +/- 7.0 cm at the age of 22.9 +/- 6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3 +/- 1.3 year. Karyotype distribution of the patients was 45X (43%), 45X/46XX (16%), 45X/46Xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4 +/- 6.9 cm vs 140.9 +/- 7.1 cm, respectively). Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS. https://turkjpediatr.org/article/view/2460 |
| spellingShingle | Abdullah Bereket Sule Can Ebru Ozerkan Mahmut Coker Sükran Darcan Behzat Ozkan Zerrin Orbak Sitki Oztaş Sükrü Palandüz Ilhan Sezgin Emre Atabek Ibrahim Erkul Metin Yildiz Pinar Işgüven Serap Turan Nursel Elçioğlu Seniha Hacihanefioğlu Nihal Memioğlu Firdevs Baş Rüveyde Bundak Feyza Darendeliler Hülya Günöz Nurçin Saka Oya Ercan Ilknur Arslanoğlu Gürbüz Erdoğan Adult height in Turkish patients with Turner syndrome without growth hormone treatment The Turkish Journal of Pediatrics |
| title | Adult height in Turkish patients with Turner syndrome without growth hormone treatment |
| title_full | Adult height in Turkish patients with Turner syndrome without growth hormone treatment |
| title_fullStr | Adult height in Turkish patients with Turner syndrome without growth hormone treatment |
| title_full_unstemmed | Adult height in Turkish patients with Turner syndrome without growth hormone treatment |
| title_short | Adult height in Turkish patients with Turner syndrome without growth hormone treatment |
| title_sort | adult height in turkish patients with turner syndrome without growth hormone treatment |
| url | https://turkjpediatr.org/article/view/2460 |
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