‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study
Abstract Objective Osteoarthritis (OA) is a disease impacting the synovial joint complex, yet transcriptional changes specific to shoulder OA remain underexplored. This study aims to profile transcriptomic changes in periarticular tissues from patients undergoing shoulder replacement for OA. By corr...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s13104-024-07035-9 |
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| author | Samuel J. Lynskey Stephen D. Gill Sean L. McGee Mark Ziemann Richard S. Page |
| author_facet | Samuel J. Lynskey Stephen D. Gill Sean L. McGee Mark Ziemann Richard S. Page |
| author_sort | Samuel J. Lynskey |
| collection | DOAJ |
| description | Abstract Objective Osteoarthritis (OA) is a disease impacting the synovial joint complex, yet transcriptional changes specific to shoulder OA remain underexplored. This study aims to profile transcriptomic changes in periarticular tissues from patients undergoing shoulder replacement for OA. By correlating these profiles with QuickDASH scores—a validated measure of worsening shoulder function—this research seeks to understand the gene expression changes associated with clinical decline. Capsular tissue biopsies from shoulder OA patients were compared with those from a control group undergoing shoulder stabilization for recurrent instability. This investigation forms part of a larger transcriptomic analysis of painful shoulder conditions which will address the current gap in knowledge regarding the molecular and genetic underpinnings of shoulder OA, rotator cuff tears and cuff-tear arthropathy. Results The analysis revealed that genes most strongly associated with increasing QuickDASH scores across tissues were linked to inflammation and stress response. Key pathways involved interleukins, chemokines, complement components, nuclear response factors, and immediate early response genes, reflecting a balance between pro- and anti-inflammatory signalling. Additionally, this study identified unique gene expression patterns in shoulder OA not previously observed in hip and knee OA, along with novel genes implicated in shoulder OA, highlighting areas for future targeted investigation. Trial registration This investigation has been registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), registered on the 26th of March 2018, registration number: 12618000431224, accessible from: https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374665&isReview=true |
| format | Article |
| id | doaj-art-b5067e7709344348ba4e92b3e45c41a5 |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-b5067e7709344348ba4e92b3e45c41a52025-08-20T01:59:42ZengBMCBMC Research Notes1756-05002024-12-011711910.1186/s13104-024-07035-9‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control studySamuel J. Lynskey0Stephen D. Gill1Sean L. McGee2Mark Ziemann3Richard S. Page4Department of Orthopaedic Surgery, Geelong University HospitalDepartment of Orthopaedic Surgery, Geelong University HospitalSchool of Medicine, Faculty of Health, Deakin UniversitySchool of Medicine, Faculty of Health, Deakin UniversityDepartment of Orthopaedic Surgery, Geelong University HospitalAbstract Objective Osteoarthritis (OA) is a disease impacting the synovial joint complex, yet transcriptional changes specific to shoulder OA remain underexplored. This study aims to profile transcriptomic changes in periarticular tissues from patients undergoing shoulder replacement for OA. By correlating these profiles with QuickDASH scores—a validated measure of worsening shoulder function—this research seeks to understand the gene expression changes associated with clinical decline. Capsular tissue biopsies from shoulder OA patients were compared with those from a control group undergoing shoulder stabilization for recurrent instability. This investigation forms part of a larger transcriptomic analysis of painful shoulder conditions which will address the current gap in knowledge regarding the molecular and genetic underpinnings of shoulder OA, rotator cuff tears and cuff-tear arthropathy. Results The analysis revealed that genes most strongly associated with increasing QuickDASH scores across tissues were linked to inflammation and stress response. Key pathways involved interleukins, chemokines, complement components, nuclear response factors, and immediate early response genes, reflecting a balance between pro- and anti-inflammatory signalling. Additionally, this study identified unique gene expression patterns in shoulder OA not previously observed in hip and knee OA, along with novel genes implicated in shoulder OA, highlighting areas for future targeted investigation. Trial registration This investigation has been registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), registered on the 26th of March 2018, registration number: 12618000431224, accessible from: https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374665&isReview=truehttps://doi.org/10.1186/s13104-024-07035-9ShoulderOsteoarthritisTranscriptomeTranscriptomicsGene expression |
| spellingShingle | Samuel J. Lynskey Stephen D. Gill Sean L. McGee Mark Ziemann Richard S. Page ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study BMC Research Notes Shoulder Osteoarthritis Transcriptome Transcriptomics Gene expression |
| title | ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study |
| title_full | ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study |
| title_fullStr | ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study |
| title_full_unstemmed | ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study |
| title_short | ‘QuickDASH’ to find unique genes and biological processes associated with shoulder osteoarthritis: a prospective case–control study |
| title_sort | quickdash to find unique genes and biological processes associated with shoulder osteoarthritis a prospective case control study |
| topic | Shoulder Osteoarthritis Transcriptome Transcriptomics Gene expression |
| url | https://doi.org/10.1186/s13104-024-07035-9 |
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