An Ectopic ACTH Secreting Metastatic Parotid Tumour
A 60-year old woman presented with features of Cushing’s syndrome (CS) secondary to an ectopic adrenocorticotropic hormone (ACTH) secreting metastatic parotid tumour 3 years after excision of the original tumour. She subsequently developed fatal intestinal perforation and unfortunately died despite...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4852907 |
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| author | Thomas Dacruz Atul Kalhan Majid Rashid Kofi Obuobie |
| author_facet | Thomas Dacruz Atul Kalhan Majid Rashid Kofi Obuobie |
| author_sort | Thomas Dacruz |
| collection | DOAJ |
| description | A 60-year old woman presented with features of Cushing’s syndrome (CS) secondary to an ectopic adrenocorticotropic hormone (ACTH) secreting metastatic parotid tumour 3 years after excision of the original tumour. She subsequently developed fatal intestinal perforation and unfortunately died despite best possible medical measures. Ectopic ACTH secretion accounts for 5–10% of all patients presenting with ACTH dependent hypercortisolism; small cell carcinoma of lung (SCLC) and neuroendocrine tumours (NET) account for the majority of such cases. Although there are 4 previous case reports of ectopic ACTH secreting salivary tumours in literature, to our knowledge this is the first published case report in which the CS developed after 3 years of what was deemed as a successful surgical excision of primary salivary tumour. Our patient initially had nonspecific symptoms which may have contributed to a delay in diagnosis. Perforation of sigmoid colon is a recognised though underdiagnosed complication associated with steroid therapy and hypercortisolism. This case demonstrates the challenges faced in diagnosis as well as management of patients with CS apart from the practical difficulties faced while trying to identify source of ectopic ACTH. |
| format | Article |
| id | doaj-art-b504ebee152646f39cfaf655d67a7345 |
| institution | OA Journals |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-b504ebee152646f39cfaf655d67a73452025-08-20T02:23:31ZengWileyCase Reports in Endocrinology2090-65012090-651X2016-01-01201610.1155/2016/48529074852907An Ectopic ACTH Secreting Metastatic Parotid TumourThomas Dacruz0Atul Kalhan1Majid Rashid2Kofi Obuobie3University Hospital of Wales, Cardiff, UKDepartment of Diabetes & Endocrinology, Royal Glamorgan Hospital, Mid Glamorgan CF72 8XR, UKRoyal Gwent Hospital, Newport, UKRoyal Gwent Hospital, Newport, UKA 60-year old woman presented with features of Cushing’s syndrome (CS) secondary to an ectopic adrenocorticotropic hormone (ACTH) secreting metastatic parotid tumour 3 years after excision of the original tumour. She subsequently developed fatal intestinal perforation and unfortunately died despite best possible medical measures. Ectopic ACTH secretion accounts for 5–10% of all patients presenting with ACTH dependent hypercortisolism; small cell carcinoma of lung (SCLC) and neuroendocrine tumours (NET) account for the majority of such cases. Although there are 4 previous case reports of ectopic ACTH secreting salivary tumours in literature, to our knowledge this is the first published case report in which the CS developed after 3 years of what was deemed as a successful surgical excision of primary salivary tumour. Our patient initially had nonspecific symptoms which may have contributed to a delay in diagnosis. Perforation of sigmoid colon is a recognised though underdiagnosed complication associated with steroid therapy and hypercortisolism. This case demonstrates the challenges faced in diagnosis as well as management of patients with CS apart from the practical difficulties faced while trying to identify source of ectopic ACTH.http://dx.doi.org/10.1155/2016/4852907 |
| spellingShingle | Thomas Dacruz Atul Kalhan Majid Rashid Kofi Obuobie An Ectopic ACTH Secreting Metastatic Parotid Tumour Case Reports in Endocrinology |
| title | An Ectopic ACTH Secreting Metastatic Parotid Tumour |
| title_full | An Ectopic ACTH Secreting Metastatic Parotid Tumour |
| title_fullStr | An Ectopic ACTH Secreting Metastatic Parotid Tumour |
| title_full_unstemmed | An Ectopic ACTH Secreting Metastatic Parotid Tumour |
| title_short | An Ectopic ACTH Secreting Metastatic Parotid Tumour |
| title_sort | ectopic acth secreting metastatic parotid tumour |
| url | http://dx.doi.org/10.1155/2016/4852907 |
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