Structural insight into the cGAS active site explains differences between therapeutically relevant species

Structural insight into the cGAS active site explains differences between therapeutically relevant species

Abstract Cyclic GMP-AMP synthase (cGAS) is an intracellular sensor of double-stranded DNA that triggers a pro-inflammatory response upon binding. The interest in cGAS as a drug discovery target has increased substantially over the past decade due to growing evidence linking its activation to numerou...

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Main Authors: Alexander M. Skeldon, Li Wang, Nicolas Sgarioto, Ramsay E. Beveridge, Silas Chan, Stephane Dorich, Valerie Dumais, Nadine Fradet, Samuel Gaudreault, Philippe LeGros, Daniel McKay, Ria Seliniotakis, Daniel V. Sietsema, Lingling Zhang, Marc-Olivier Boily, Jason D. Burch, Alex Caron, Lee D. Fader, Lodoe Lama, Wei Xie, Dinshaw J. Patel, Thomas Tuschl, Michael A. Crackower, Kelly A. Pike
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01481-7
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