Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat
Objective: This study was designed to evaluate the protective role of L-arginine on body weight, and absolute and relative kidney weight of Streptozotocin (STZ)-treated albino rats. Methodology: This experimental study was conducted in the department of Anatomy, Basic Medical Sciences Institute (BM...
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Bahria Univerisy Health Sciences, Campus Karachi
2017-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/223 |
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| author | Yasmeen Mahar Humera Waqar Sahal Salman |
| author_facet | Yasmeen Mahar Humera Waqar Sahal Salman |
| author_sort | Yasmeen Mahar |
| collection | DOAJ |
| description |
Objective: This study was designed to evaluate the protective role of L-arginine on body weight, and absolute and relative
kidney weight of Streptozotocin (STZ)-treated albino rats.
Methodology: This experimental study was conducted in the department of Anatomy, Basic Medical Sciences Institute (BMSI),
Jinnah Postgraduate Medical Centre (JPMC), Karachi, from February to March, 2010. In this study, 30 male albino rats were
divided into 3 groups, containing 10 animals each. Group-A was treated as control. Group-B animals received STZ in a dose
of 37 mg/kg intraperitoneally (I/P) only once at the start of experiment. Group-C received L-arginine orally in a dose of 0.3
mg/100 gram (G)body weight/day a week before STZ treatment.
Results: There was a highly significant increase in serum glucose level in group B animals when compared to the control group
A. In group C, the serum glucose levels returned near to control. The final body weight of group B animals decreased significantly
when compared to their initial weight, as well as when compared to control. The data also showed that there was a significant
decrease in absolute kidney weight whereas, significant increase in relative kidney weight in group B animals when compared
to group A animals respectively. There was significant restoration of body weight, and absolute and relative kidney weight in
group C animals receiving L-arginine along with STZ.
Conclusion: Our findings conclude that L-arginine as a nitric oxide donor and as an antioxidant, plays a significant role in
preserving renal morphology in streptozotocin-treated hyperglycemic rats.
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| format | Article |
| id | doaj-art-b5000a5330d24fe8b66a59ee7dbf0b21 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-b5000a5330d24fe8b66a59ee7dbf0b212025-08-20T02:45:02ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822017-03-0171Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino RatYasmeen MaharHumera WaqarSahal Salman Objective: This study was designed to evaluate the protective role of L-arginine on body weight, and absolute and relative kidney weight of Streptozotocin (STZ)-treated albino rats. Methodology: This experimental study was conducted in the department of Anatomy, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi, from February to March, 2010. In this study, 30 male albino rats were divided into 3 groups, containing 10 animals each. Group-A was treated as control. Group-B animals received STZ in a dose of 37 mg/kg intraperitoneally (I/P) only once at the start of experiment. Group-C received L-arginine orally in a dose of 0.3 mg/100 gram (G)body weight/day a week before STZ treatment. Results: There was a highly significant increase in serum glucose level in group B animals when compared to the control group A. In group C, the serum glucose levels returned near to control. The final body weight of group B animals decreased significantly when compared to their initial weight, as well as when compared to control. The data also showed that there was a significant decrease in absolute kidney weight whereas, significant increase in relative kidney weight in group B animals when compared to group A animals respectively. There was significant restoration of body weight, and absolute and relative kidney weight in group C animals receiving L-arginine along with STZ. Conclusion: Our findings conclude that L-arginine as a nitric oxide donor and as an antioxidant, plays a significant role in preserving renal morphology in streptozotocin-treated hyperglycemic rats. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/223Hyperglycemia, Kidney, L-arginine, Streptozotocin. |
| spellingShingle | Yasmeen Mahar Humera Waqar Sahal Salman Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat Journal of Bahria University Medical and Dental College Hyperglycemia, Kidney, L-arginine, Streptozotocin. |
| title | Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat |
| title_full | Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat |
| title_fullStr | Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat |
| title_full_unstemmed | Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat |
| title_short | Protective Effect of L-Arginine on Streptozotocin-Induced Diabetic Nephropathy in Albino Rat |
| title_sort | protective effect of l arginine on streptozotocin induced diabetic nephropathy in albino rat |
| topic | Hyperglycemia, Kidney, L-arginine, Streptozotocin. |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/223 |
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