Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?
Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis. Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic fe...
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Medical Network
2021-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/949 |
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| author | Nevin Tuten Serdar Acikgoz Zahid Mammadov Eduard Malik Abdullah Tuten Onur Guralp |
| author_facet | Nevin Tuten Serdar Acikgoz Zahid Mammadov Eduard Malik Abdullah Tuten Onur Guralp |
| author_sort | Nevin Tuten |
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Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.
Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.
Results: The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).
Conclusion: The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma.
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| format | Article |
| id | doaj-art-b4fb5c006d8b4ff7aa867d1acd95b7bf |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Medical Network |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-b4fb5c006d8b4ff7aa867d1acd95b7bf2025-02-11T21:13:00ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-08-0127210.21613/GORM.2019.949Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?Nevin Tuten0Serdar Acikgoz1Zahid Mammadov2Eduard Malik3Abdullah Tuten4Onur Guralp5Darende State Hospital, Obstetrics and Gynecology Zaviye Mah. Hacı Hulusi Efendi Cad. No No:22, 44700, Darende/Malatya, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, TurkeyAtakent Acıbadem Hospital, Department of Obstetrics and Gynecology, Halkalı Altınşehir İstanbul Cd. No:16, 34303 Küçükçekmece, Istanbul, TurkeyCarl von Ossietzky Oldenburg University, Department of Obstetrics and Gynecology, Klinikum Oldenburg, AöR, Rahel-Strauß-Straße 10, 26133, Oldenburg, GermanyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, TurkeyOldenburg University, Department of Obstetrics and Gynecology,Klinikum Oldenburg, Oldenburg Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis. Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared. Results: The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267). Conclusion: The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma. https://gorm.com.tr/index.php/GORM/article/view/94925-hydroxy vitamin DDysmenorrheaEndometriomaEndometriosisVitamin D |
| spellingShingle | Nevin Tuten Serdar Acikgoz Zahid Mammadov Eduard Malik Abdullah Tuten Onur Guralp Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? Gynecology Obstetrics & Reproductive Medicine 25-hydroxy vitamin D Dysmenorrhea Endometrioma Endometriosis Vitamin D |
| title | Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? |
| title_full | Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? |
| title_fullStr | Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? |
| title_full_unstemmed | Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? |
| title_short | Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? |
| title_sort | is there a role of 25 hydroxy vitamin d in the pathogenesis of mild and moderate to severe endometriosis |
| topic | 25-hydroxy vitamin D Dysmenorrhea Endometrioma Endometriosis Vitamin D |
| url | https://gorm.com.tr/index.php/GORM/article/view/949 |
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