Transformation of Linear Alkenyl <i>N</i>-Alkoxy Carbamates into Cyclic Bromo Carbonates

We present a protocol for the facile conversion of linear alkenyl <i>N</i>-alkoxy carbamates into cyclic bromo carbonates. The reaction is operationally simple, uses widely available, inexpensive reagents, and requires no rigorous exclusion of air or moisture. A range of functional group...

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Bibliographic Details
Main Authors: Shyam Sathyamoorthi, Steven P. Kelley
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Chemistry
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Online Access:https://www.mdpi.com/2624-8549/7/3/99
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Summary:We present a protocol for the facile conversion of linear alkenyl <i>N</i>-alkoxy carbamates into cyclic bromo carbonates. The reaction is operationally simple, uses widely available, inexpensive reagents, and requires no rigorous exclusion of air or moisture. A range of functional groups is compatible, and the reaction diastereoselectivities vary from good to excellent. The reactions are scalable, and the resultant carbonates can be further transformed.
ISSN:2624-8549