Sevoflurane reduces brain edema and improves blood-brain barrier by downregulating CaMKII to inhibit TMEM16A after cerebral ischemia injury both in vivo and in vitro

Sevoflurane reduces brain edema and improves blood-brain barrier by downregulating CaMKII to inhibit TMEM16A after cerebral ischemia injury both in vivo and in vitro

This study aimed to investigate whether sevoflurane could reduce brain edema and protect blood-brain barrier (BBB) after cerebral-ischemia injury in vivo and in vitro via calmodulin-dependent protein kinase II (CaMKII)/ transmembrane protein 16A (TMEM16A) pathway. Adult male Sprague-Dawley rats and...

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Bibliographic Details
Main Authors: Jingbin Zhang, Yuhe Tian, Ruixue Wang, Xinlei Qin, Quntao Li, Ketao Ma, Junqiang Si, Dong Zhao, Yan Li, Jiangwen Yin
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
sevoflurane
transmembrane protein 16 A
calmodulin-dependent protein kinase II
cerebral ischemia
brain edema
blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002916
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