Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial
Abstract Background Allergic rhinitis (AR) is a common allergic condition characterized by frequent sneezing, nasal congestion, nasal itching and rhinorrhea. Chinese medicine formula Yu-Ping-Feng Powder with Variation (YPV) is an empirical formula modified from an ancient Chinese medicine formula na...
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BMC
2025-05-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01120-2 |
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| author | Zhi-Xiu Lin Tin Muk Ho Yan-Fang Xian Kam Leung Chan Qing-Qing Xu Cho Wing Lo Justin Che Yuen Wu Kam Lun Hon Sin Bond Leung Chon Pin Chia Chi Him Sum Tak Yee Chow Pui Kuan Cheong Jessica Yuet Ling Ching Hongwei Zhang Ka Chun Leung Wai Ling Lin |
| author_facet | Zhi-Xiu Lin Tin Muk Ho Yan-Fang Xian Kam Leung Chan Qing-Qing Xu Cho Wing Lo Justin Che Yuen Wu Kam Lun Hon Sin Bond Leung Chon Pin Chia Chi Him Sum Tak Yee Chow Pui Kuan Cheong Jessica Yuet Ling Ching Hongwei Zhang Ka Chun Leung Wai Ling Lin |
| author_sort | Zhi-Xiu Lin |
| collection | DOAJ |
| description | Abstract Background Allergic rhinitis (AR) is a common allergic condition characterized by frequent sneezing, nasal congestion, nasal itching and rhinorrhea. Chinese medicine formula Yu-Ping-Feng Powder with Variation (YPV) is an empirical formula modified from an ancient Chinese medicine formula named Yu-Ping-Feng Powder, which is widely used for the treatment of allergic diseases such as AR and asthma. Purpose To evaluate the efficacy and safety of YPV on AR patients with the lung and spleen Qi deficiency type using a randomized, double-blind, placebo-controlled clinical trial (RCT). Study design and methods Between April 2022 and June 2023, a total of 58 participants were recruited and randomly allocated to receive either YPV (n = 29) or placebo (n = 29) for 8 consecutive weeks. The changes of the Total Nasal Symptom Score (TNSS), and the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) or the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) scores at week 8 were used as the primary outcomes. The secondary outcomes included (1) the change of TNSS at weeks 4, 12 and 16; (2) the RQLQ or the PADQLQ scores at weeks 4, 12 and 16; (3) the change of frequency of AR episodes and their severity Visual Analog Scale (VAS) at weeks 4, 8, 12 and 16; (4) the changes of the gut microbiota composition in stool samples at week 8; and (5) adverse events related to the study treatment. Results YPV treatment could significantly improve the RQLQ score in AR patients at weeks 4, 8, 12, and 16 (p = 0.05, p = 0.04, p = 0.04 and p = 0.03, respectively), when compared with the placebo treatment. However, it did not improve the TNSS score at week 8 in AR patients when compared with the placebo group. In addition, YPV treatment could reduce the VAS score in AR patients at weeks 12 and 16 when compared with the placebo group, although the reductions were not statistically significant (p = 0.06 and p = 0.08, respectively). Importantly, no overt adverse effects were observed in both YPV and placebo groups. Conclusion YPV was well-tolerated and could effectively ameliorate multiple symptoms of AR and improve the quality of life of AR patients after 8-week treatment. Trial registration ClinicalTrials.gov, NCT04976023. Registered 26 July 2021, https://clinicaltrials.gov/study/NCT04976023?cond=The%20Effects%20of%20Using%20Yupingfeng%20Powder%20with%20Variation%20for%20the%20Treatment%20of%20Allergic%20Rhinitis&rank=2 |
| format | Article |
| id | doaj-art-b4f6ed5becab440185b970d147abf44f |
| institution | DOAJ |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-b4f6ed5becab440185b970d147abf44f2025-08-20T03:16:41ZengBMCChinese Medicine1749-85462025-05-0120111510.1186/s13020-025-01120-2Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trialZhi-Xiu Lin0Tin Muk Ho1Yan-Fang Xian2Kam Leung Chan3Qing-Qing Xu4Cho Wing Lo5Justin Che Yuen Wu6Kam Lun Hon7Sin Bond Leung8Chon Pin Chia9Chi Him Sum10Tak Yee Chow11Pui Kuan Cheong12Jessica Yuet Ling Ching13Hongwei Zhang14Ka Chun Leung15Wai Ling Lin16School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongHong Kong Institute of Integrative Medicine, Faculty of Medicine, The Chinese University of Hong KongSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong KongAbstract Background Allergic rhinitis (AR) is a common allergic condition characterized by frequent sneezing, nasal congestion, nasal itching and rhinorrhea. Chinese medicine formula Yu-Ping-Feng Powder with Variation (YPV) is an empirical formula modified from an ancient Chinese medicine formula named Yu-Ping-Feng Powder, which is widely used for the treatment of allergic diseases such as AR and asthma. Purpose To evaluate the efficacy and safety of YPV on AR patients with the lung and spleen Qi deficiency type using a randomized, double-blind, placebo-controlled clinical trial (RCT). Study design and methods Between April 2022 and June 2023, a total of 58 participants were recruited and randomly allocated to receive either YPV (n = 29) or placebo (n = 29) for 8 consecutive weeks. The changes of the Total Nasal Symptom Score (TNSS), and the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) or the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) scores at week 8 were used as the primary outcomes. The secondary outcomes included (1) the change of TNSS at weeks 4, 12 and 16; (2) the RQLQ or the PADQLQ scores at weeks 4, 12 and 16; (3) the change of frequency of AR episodes and their severity Visual Analog Scale (VAS) at weeks 4, 8, 12 and 16; (4) the changes of the gut microbiota composition in stool samples at week 8; and (5) adverse events related to the study treatment. Results YPV treatment could significantly improve the RQLQ score in AR patients at weeks 4, 8, 12, and 16 (p = 0.05, p = 0.04, p = 0.04 and p = 0.03, respectively), when compared with the placebo treatment. However, it did not improve the TNSS score at week 8 in AR patients when compared with the placebo group. In addition, YPV treatment could reduce the VAS score in AR patients at weeks 12 and 16 when compared with the placebo group, although the reductions were not statistically significant (p = 0.06 and p = 0.08, respectively). Importantly, no overt adverse effects were observed in both YPV and placebo groups. Conclusion YPV was well-tolerated and could effectively ameliorate multiple symptoms of AR and improve the quality of life of AR patients after 8-week treatment. Trial registration ClinicalTrials.gov, NCT04976023. Registered 26 July 2021, https://clinicaltrials.gov/study/NCT04976023?cond=The%20Effects%20of%20Using%20Yupingfeng%20Powder%20with%20Variation%20for%20the%20Treatment%20of%20Allergic%20Rhinitis&rank=2https://doi.org/10.1186/s13020-025-01120-2Allergic rhinitisYu-Ping-Feng powder with variation (YPV)RCT |
| spellingShingle | Zhi-Xiu Lin Tin Muk Ho Yan-Fang Xian Kam Leung Chan Qing-Qing Xu Cho Wing Lo Justin Che Yuen Wu Kam Lun Hon Sin Bond Leung Chon Pin Chia Chi Him Sum Tak Yee Chow Pui Kuan Cheong Jessica Yuet Ling Ching Hongwei Zhang Ka Chun Leung Wai Ling Lin Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial Chinese Medicine Allergic rhinitis Yu-Ping-Feng powder with variation (YPV) RCT |
| title | Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
| title_full | Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
| title_fullStr | Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
| title_short | Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
| title_sort | exploring the efficacy and safety of yu ping feng powder with variation against allergic rhinitis a randomized double blind placebo controlled trial |
| topic | Allergic rhinitis Yu-Ping-Feng powder with variation (YPV) RCT |
| url | https://doi.org/10.1186/s13020-025-01120-2 |
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