Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage?
Esophageal variceal hemorrhage occurs in up to 10% of children with portal hypertension annually, and may be fatal. In contrast to the strong evidence in adults that nonselective beta-adrenergic antagonism reduces the risk of variceal bleeding by approximately 50%, few pediatric data are available....
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/935161 |
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| _version_ | 1832545805836222464 |
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| author | Simon C Ling |
| author_facet | Simon C Ling |
| author_sort | Simon C Ling |
| collection | DOAJ |
| description | Esophageal variceal hemorrhage occurs in up to 10% of children with portal hypertension annually, and may be fatal. In contrast to the strong evidence in adults that nonselective beta-adrenergic antagonism reduces the risk of variceal bleeding by approximately 50%, few pediatric data are available. The use of beta-blockers for primary prophylaxis has been reported in children, but not tested in a randomized controlled trial. The risks and benefits in children remain unquantified and may differ from adults in light of the different cardiovascular response to hypovolemia in young children. The circumstances of the individual patient must, therefore, be carefully considered before beta-blockers are prescribed to children with esophageal varices. |
| format | Article |
| id | doaj-art-b4f157f8085945efa2e7955738f5ccee |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-b4f157f8085945efa2e7955738f5ccee2025-02-03T07:24:41ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-01191166166610.1155/2005/935161Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage?Simon C Ling0Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, CanadaEsophageal variceal hemorrhage occurs in up to 10% of children with portal hypertension annually, and may be fatal. In contrast to the strong evidence in adults that nonselective beta-adrenergic antagonism reduces the risk of variceal bleeding by approximately 50%, few pediatric data are available. The use of beta-blockers for primary prophylaxis has been reported in children, but not tested in a randomized controlled trial. The risks and benefits in children remain unquantified and may differ from adults in light of the different cardiovascular response to hypovolemia in young children. The circumstances of the individual patient must, therefore, be carefully considered before beta-blockers are prescribed to children with esophageal varices.http://dx.doi.org/10.1155/2005/935161 |
| spellingShingle | Simon C Ling Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? Canadian Journal of Gastroenterology |
| title | Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? |
| title_full | Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? |
| title_fullStr | Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? |
| title_full_unstemmed | Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? |
| title_short | Should Children with Esophageal Varices Receive Beta-Blockers for the Primary Prevention of Variceal Hemorrhage? |
| title_sort | should children with esophageal varices receive beta blockers for the primary prevention of variceal hemorrhage |
| url | http://dx.doi.org/10.1155/2005/935161 |
| work_keys_str_mv | AT simoncling shouldchildrenwithesophagealvaricesreceivebetablockersfortheprimarypreventionofvaricealhemorrhage |