Effects of stachydrine on podocyte injury in diabetic nephropathy rats by regulating the SDF-1/CXCR4 signaling pathway

Effects of stachydrine on podocyte injury in diabetic nephropathy rats by regulating the SDF-1/CXCR4 signaling pathway

ObjectiveTo investigate the effect of stachydrine （Sta） on podocyte injury in rats with diabetic nephropathy （DKD） by regulating the stromal cell derived factor-1（SDF-1）/chemokine receptor-4（CXCR4） signaling pathway.MethodsRats were randomly separated into the Control group， Model group， low-dose St...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tong Ai-ping, Wang Huai-huai, Sun Hong-li, Wang Hui-fang, Wei Xiao-yan, Jia Jun-li
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Nephrology 2025-06-01
Series:	Linchuang shenzangbing zazhi
Subjects:	Stachydrine SDF-1/CXCR4 signaling pathway Diabetic kidney disease Rat Podocytes
Online Access:	http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.06.009
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway
by: Mohamed Awad, et al.
Published: (2024-12-01)

Mechanism of Bushen Zhuangjin Decoction to Promote BMSCs Homing and Protect Articular Cartilage in Mice by the SDF-1/CXCR4 Axis
by: HUANG Yanfeng, et al.
Published: (2024-02-01)

Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway
by: Yang Gui, et al.
Published: (2025-02-01)

Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis
by: Lin Zheng, et al.
Published: (2024-07-01)

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis
by: Lin Zheng, et al.
Published: (2025-08-01)

Stachydrine from Natural Foods Alleviates Hyperuricemia by Modulating Renal Urate Transporters and Suppressing Mitochondrial Oxidative Stress
by: Jian Guo, et al.
Published: (2025-05-01)

CAF-mediated regulation of prostate cancer stem cell stemness via the Wnt/β-catenin and SDF-1/CXCR4 pathways in castration-resistant prostate cancer
by: Haoran Chen, et al.
Published: (2025-07-01)

A scanning electron microscopic studies on the podocytes of the kidneys of rat (rattus norvegicus) and blind mole rat (spalax leucodon)
by: İsmail Hakkı Nur, et al.

Tacrolimus repairs glomerular podocytes injury in rats with adriamycin induced nephropathy
by: CHEN Cai-ming, et al.
Published: (2020-01-01)

Modulation of podocyte autophagy and migration by advanced glycationend products through Wnt/β-catenin signaling pathway
by: ZHANG Li, et al.
Published: (2018-01-01)

Modified Huangqi Chifeng decoction alleviates podocyte injury on rat with experimental membranous nephropathy
by: Meiying Chang, et al.
Published: (2025-12-01)

The effects of canonical Wnt signaling pathways on the CXCR4 expression of bone marrow derived mesenchymal stem cells
by: SUN Ji-ping, et al.
Published: (2017-01-01)

Podocyte epithelial-mesenchymal transdifferentiation and glomerular disease
by: CHEN Hai-yun, et al.
Published: (2020-01-01)

RS-SpecSDF: Reflection-supervised surface reconstruction and material estimation for specular indoor scenes
by: Dong-Yu Chen, et al.
Published: (2025-08-01)

Expressions of nephrin and desmin in podocyte of HUA rats and intervention of febuxostat
by: Wu Wei-bin, et al.
Published: (2021-01-01)

Podocyte dysfunction driven by heme in sickle-cell nephropathy
by: Chloé Ben Ali, et al.
Published: (2025-07-01)

Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis
by: Daoyuan Lv, et al.
Published: (2025-02-01)

Effects of dapagliflozin on podocyte damage and oxidative stress in patients with diabetic nephropathy
by: Yajing Shi, et al.
Published: (2025-08-01)

Efficacy of diode laser application versus silver diamine fluoride (SDF) as a modification of Hall technique in primary teeth
by: Ghada A. Salem, et al.
Published: (2022-12-01)

CXCR4 and CXCR6 dually limit T cell entry into the polyomavirus-infected brain
by: Kalynn M. Alexander, et al.
Published: (2025-06-01)

CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus
by: Chen X, et al.
Published: (2024-12-01)

Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling
by: Eike Schwartze, et al.
Published: (2025-06-01)

Renalase protects against podocyte injury by inhibiting oxidative stress and apoptosis in diabetic nephropathy
by: Wu Yiru, et al.
Published: (2024-11-01)

The research progress of podocytes in crescentic glomerulonephritis
by: ZOU Rong, et al.
Published: (2020-01-01)

The protective effect of astragaloside IV on puromycin aminonucleoside induced podocyte injury and its potential mechanism
by: GONG Jian-guang, et al.
Published: (2020-01-01)

Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models
by: Lucas A. Horn, et al.
Published: (2024-12-01)

Sirt6 ameliorates high glucose-induced podocyte cytoskeleton remodeling via the PI3K/AKT signaling pathway
by: Zongwei Zhang, et al.
Published: (2024-12-01)

Detection of VipAlbumin® Effect in CD34 and SDF-1 Mobilization, in Streptozotocin-induced Diabetes Mellitus Mice
by: Andi Rizki Adi Pradana, et al.
Published: (2015-06-01)

Inhibition of angiotensin Ⅱ type 1 receptor on Renal Fibrosis and Podocyte Damage in Angiotensin Ⅱ-induced Hypertensive Nephropathy
by: Zhang He-ping, et al.
Published: (2022-04-01)

Protective Role of the Podocyte IL-15 / STAT5 Pathway in Focal Segmental Glomerulosclerosis
by: Aïssata Niasse, et al.
Published: (2024-04-01)

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma
by: Qianqian Cao, et al.
Published: (2025-08-01)

Effects of lycopene on high glucose-induced autophagy and apoptosis of podocytes
by: LI Ni, et al.
Published: (2018-01-01)

CXCR3 inhibitors for therapeutic interventions: current status and perspectives
by: Rongrong Huo, et al.
Published: (2025-07-01)

Nano-Silicate-Reinforced and SDF-1β-Loaded Gelatin-Methacryloyl Hydrogel for Bone Tissue Engineering [Retraction]
by: Shi Z, et al.
Published: (2025-02-01)

Research on podocyte injury mechanisms in diabetic nephropathy: a bibliometric and knowledge-map analysis from 2000 to 2024
by: Yanmei Lin, et al.
Published: (2025-08-01)

Expression of DKK3 in chronic glomerulonephritis tissues and its induction of migration of glomerular podocytes
by: XU Wei-jia, et al.
Published: (2019-01-01)

Columbianetin protects from high-glycemic podocyte damage by regulating autophagy
by: Shi Lang, et al.
Published: (2021-01-01)

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases
by: Chao Zhou, et al.
Published: (2025-05-01)

The Number and Size of Glomeruli and Podocytes in the Aging Human Kidney
by: Kotaro Haruhara, et al.
Published: (2025-07-01)

Preparation of SDF-1α-loaded electrospun coaxial microspheres and their study on promoting migration and differentiation of dental pulp stem cells
by: Wenjie Feng, et al.
Published: (2025-06-01)