Roles of ribosomal proteins in hematologic disorders and cancers: a review
Abstract. Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation. In addition, ribosomal proteins also pe...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2023-03-01
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| Series: | Emergency and Critical Care Medicine |
| Online Access: | http://journals.lww.com/10.1097/EC9.0000000000000014 |
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| author | Jie Wang Feng Yan |
| author_facet | Jie Wang Feng Yan |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Abstract. Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation. In addition, ribosomal proteins also perform extra-ribosomal functions, such as participating in DNA replication, transcription, and damage repair, regulating cell growth, proliferation, apoptosis, and transformation. In recent years, studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases, including Diamond-Blackfan anemia, 5q-syndrome, Shwachman-Diamond syndrome, and other blood system diseases. Moreover, abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors. In this review, we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal, prostate, gastric, esophageal, and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers. |
| format | Article |
| id | doaj-art-b4f0b4cbb2884a33bb54d99dfe5cc27c |
| institution | OA Journals |
| issn | 2097-0617 2693-860X |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Emergency and Critical Care Medicine |
| spelling | doaj-art-b4f0b4cbb2884a33bb54d99dfe5cc27c2025-08-20T01:54:12ZengWolters Kluwer Health/LWWEmergency and Critical Care Medicine2097-06172693-860X2023-03-0131233110.1097/EC9.0000000000000014202303000-00006Roles of ribosomal proteins in hematologic disorders and cancers: a reviewJie Wang0Feng Yan1a Shandong Key Laboratory of Cardiovascular Proteomics, Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, Chinab Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China.Abstract. Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation. In addition, ribosomal proteins also perform extra-ribosomal functions, such as participating in DNA replication, transcription, and damage repair, regulating cell growth, proliferation, apoptosis, and transformation. In recent years, studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases, including Diamond-Blackfan anemia, 5q-syndrome, Shwachman-Diamond syndrome, and other blood system diseases. Moreover, abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors. In this review, we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal, prostate, gastric, esophageal, and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers.http://journals.lww.com/10.1097/EC9.0000000000000014 |
| spellingShingle | Jie Wang Feng Yan Roles of ribosomal proteins in hematologic disorders and cancers: a review Emergency and Critical Care Medicine |
| title | Roles of ribosomal proteins in hematologic disorders and cancers: a review |
| title_full | Roles of ribosomal proteins in hematologic disorders and cancers: a review |
| title_fullStr | Roles of ribosomal proteins in hematologic disorders and cancers: a review |
| title_full_unstemmed | Roles of ribosomal proteins in hematologic disorders and cancers: a review |
| title_short | Roles of ribosomal proteins in hematologic disorders and cancers: a review |
| title_sort | roles of ribosomal proteins in hematologic disorders and cancers a review |
| url | http://journals.lww.com/10.1097/EC9.0000000000000014 |
| work_keys_str_mv | AT jiewang rolesofribosomalproteinsinhematologicdisordersandcancersareview AT fengyan rolesofribosomalproteinsinhematologicdisordersandcancersareview |