Review on Trypanosoma cruzi: Host Cell Interaction
Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyc...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2010/295394 |
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| _version_ | 1850159489455489024 |
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| author | Wanderley de Souza Tecia Maria Ulisses de Carvalho Emile Santos Barrias |
| author_facet | Wanderley de Souza Tecia Maria Ulisses de Carvalho Emile Santos Barrias |
| author_sort | Wanderley de Souza |
| collection | DOAJ |
| description | Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the feces of the insect while amastigotes and bloodstream trypomastigotes are released from the infected host cells of the vertebrate host after a complex intracellular life cycle. The recognition between parasite and mammalian host cell involves numerous molecules present in both cell types. Here, we present a brief review of the interaction between Trypanosoma cruzi and its host cells, mainly emphasizing the mechanisms and molecules that participate in the T. cruzi invasion process of the mammalian cells. |
| format | Article |
| id | doaj-art-b4f069a490e349eb9d96d984629181fd |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-b4f069a490e349eb9d96d984629181fd2025-08-20T02:23:31ZengWileyInternational Journal of Cell Biology1687-88761687-88842010-01-01201010.1155/2010/295394295394Review on Trypanosoma cruzi: Host Cell InteractionWanderley de Souza0Tecia Maria Ulisses de Carvalho1Emile Santos Barrias2Laboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, Ilha do Fundão, RJ 21941-902, BrazilLaboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, Ilha do Fundão, RJ 21941-902, BrazilLaboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, Ilha do Fundão, RJ 21941-902, BrazilTrypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the feces of the insect while amastigotes and bloodstream trypomastigotes are released from the infected host cells of the vertebrate host after a complex intracellular life cycle. The recognition between parasite and mammalian host cell involves numerous molecules present in both cell types. Here, we present a brief review of the interaction between Trypanosoma cruzi and its host cells, mainly emphasizing the mechanisms and molecules that participate in the T. cruzi invasion process of the mammalian cells.http://dx.doi.org/10.1155/2010/295394 |
| spellingShingle | Wanderley de Souza Tecia Maria Ulisses de Carvalho Emile Santos Barrias Review on Trypanosoma cruzi: Host Cell Interaction International Journal of Cell Biology |
| title | Review on Trypanosoma cruzi: Host Cell Interaction |
| title_full | Review on Trypanosoma cruzi: Host Cell Interaction |
| title_fullStr | Review on Trypanosoma cruzi: Host Cell Interaction |
| title_full_unstemmed | Review on Trypanosoma cruzi: Host Cell Interaction |
| title_short | Review on Trypanosoma cruzi: Host Cell Interaction |
| title_sort | review on trypanosoma cruzi host cell interaction |
| url | http://dx.doi.org/10.1155/2010/295394 |
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