Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer

Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer

Purpose: We conducted a prospective, single-institution phase II trial to test the hypothesis that the addition of nivolumab to definitive chemoradiation would improve the progression-free survival (PFS) among patients with high-risk p16+ oropharyngeal squamous cell carcinoma (OPSCC). Methods and Ma...

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Main Authors: Samuel Nicholas Regan, MD, Jennifer Shah, MD, Krithika Suresh, PhD, Krystal A. Morales, MD, PhD, Yue Cao, PhD, Madhava Aryal, PhD, Benjamin S. Rosen, PhD, Heather Walline, PhD, Choonik Lee, PhD, Jessica Aldous, BS, Paul L. Swiecicki, MD, Keith A. Casper, MD, Steven B. Chinn, MD, Kelly M. Malloy, MD, Mark E.P. Prince, MD, Chaz L. Stucken, MD, Andrew G. Shuman, MD, Molly Heft-Neal, MD, Teresa H. Lyden, MA, CCC-SLP, Anna Blakely, MA, CCC-SLP, Madison Ambrose, MA, CCC-SLP, John Chad Brenner, PhD, Francis P. Worden, MD, Michelle L. Mierzwa, MD
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109425001198
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