The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.

The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.

Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an ani...

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Bibliographic Details
Main Authors: Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198490/1/pone.0198490.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134708Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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