Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study
Background: The Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) study was an 18-month prospective, observational, non-interventional research study focused on patients with mild cognitive impairment (MCI) following ischemic stroke. Objectives: Our secondary analysis of the IHCNP...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Neurology International |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2035-8377/16/6/118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850058493556424704 |
|---|---|
| author | Dragoș-Cătălin Jianu Ligia Petrica Traian Flavius Dan Georgiana Munteanu Bianca Bora Sergiu Florin Arnăutu Sorin Ursoniu Diana Chira Ștefan Strilciuc Cristian Falup-Pecurariu Dafin Fior Mureșanu |
| author_facet | Dragoș-Cătălin Jianu Ligia Petrica Traian Flavius Dan Georgiana Munteanu Bianca Bora Sergiu Florin Arnăutu Sorin Ursoniu Diana Chira Ștefan Strilciuc Cristian Falup-Pecurariu Dafin Fior Mureșanu |
| author_sort | Dragoș-Cătălin Jianu |
| collection | DOAJ |
| description | Background: The Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) study was an 18-month prospective, observational, non-interventional research study focused on patients with mild cognitive impairment (MCI) following ischemic stroke. Objectives: Our secondary analysis of the IHCNP data aimed to document the progression of MCI in this patient group. Methods: A total of 100 patients from Romania were recruited, all of whom underwent cognitive assessments using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Rey Auditory Verbal Learning Test (RAVLT). Clinical evaluations were also conducted as part of the study. Baseline cognitive scores were recorded, and subsequent follow-ups documented cognitive changes over time. Results: At baseline, cognitive scores indicated mild impairment, with averages of MMSE 25.41, MoCA 23.27, and RAVLT 33.63. By the end of the study, patients exhibited a significant cognitive decline, with MMSE scores dropping by 8.7%, MoCA by 10.0%, and RAVLT by 29.5% (<i>p</i> < 0.0001 for all measures), reflecting the progressive nature of MCI post-stroke. Conclusions: These findings highlight the importance of early diagnosis and intervention to mitigate cognitive decline in post-stroke patients. The study underscores the need for ongoing cognitive monitoring to improve patient outcomes and manage MCI progression effectively. |
| format | Article |
| id | doaj-art-b4e8ca8ad7474753967ebf5c4f398b9f |
| institution | DOAJ |
| issn | 2035-8377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-b4e8ca8ad7474753967ebf5c4f398b9f2025-08-20T02:51:07ZengMDPI AGNeurology International2035-83772024-11-011661626163510.3390/neurolint16060118Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) StudyDragoș-Cătălin Jianu0Ligia Petrica1Traian Flavius Dan2Georgiana Munteanu3Bianca Bora4Sergiu Florin Arnăutu5Sorin Ursoniu6Diana Chira7Ștefan Strilciuc8Cristian Falup-Pecurariu9Dafin Fior Mureșanu10First Division of Neurology, Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, E. Murgu Sq., No. 2, 300041 Timisoara, RomaniaAdvanced Centre for Cognitive Research in Neuropsychiatric Pathology (NeuroPsy-Cog), Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, 156 L. Rebreanu Ave., 300736 Timisoara, RomaniaFirst Division of Neurology, Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, E. Murgu Sq., No. 2, 300041 Timisoara, RomaniaFirst Division of Neurology, Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, E. Murgu Sq., No. 2, 300041 Timisoara, RomaniaFirst Division of Neurology, Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, E. Murgu Sq., No. 2, 300041 Timisoara, RomaniaAdvanced Centre for Cognitive Research in Neuropsychiatric Pathology (NeuroPsy-Cog), Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, 156 L. Rebreanu Ave., 300736 Timisoara, RomaniaAdvanced Centre for Cognitive Research in Neuropsychiatric Pathology (NeuroPsy-Cog), Department of Neurosciences-VIII, “Victor Babes” University of Medicine and Pharmacy, 156 L. Rebreanu Ave., 300736 Timisoara, RomaniaRoNeuro Institute for Neurological Research and Diagnostics, 37 Mircea Eliade St., 400364 Cluj-Napoca, RomaniaRoNeuro Institute for Neurological Research and Diagnostics, 37 Mircea Eliade St., 400364 Cluj-Napoca, RomaniaDepartment of Neurology, County Clinic Hospital, 25 Calea Bucuresti, 500365 Brașov, RomaniaRoNeuro Institute for Neurological Research and Diagnostics, 37 Mircea Eliade St., 400364 Cluj-Napoca, RomaniaBackground: The Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) study was an 18-month prospective, observational, non-interventional research study focused on patients with mild cognitive impairment (MCI) following ischemic stroke. Objectives: Our secondary analysis of the IHCNP data aimed to document the progression of MCI in this patient group. Methods: A total of 100 patients from Romania were recruited, all of whom underwent cognitive assessments using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Rey Auditory Verbal Learning Test (RAVLT). Clinical evaluations were also conducted as part of the study. Baseline cognitive scores were recorded, and subsequent follow-ups documented cognitive changes over time. Results: At baseline, cognitive scores indicated mild impairment, with averages of MMSE 25.41, MoCA 23.27, and RAVLT 33.63. By the end of the study, patients exhibited a significant cognitive decline, with MMSE scores dropping by 8.7%, MoCA by 10.0%, and RAVLT by 29.5% (<i>p</i> < 0.0001 for all measures), reflecting the progressive nature of MCI post-stroke. Conclusions: These findings highlight the importance of early diagnosis and intervention to mitigate cognitive decline in post-stroke patients. The study underscores the need for ongoing cognitive monitoring to improve patient outcomes and manage MCI progression effectively.https://www.mdpi.com/2035-8377/16/6/118mild cognitive impairmentdementiaMontreal Cognitive Assessmentneurologypsychiatryvascular cognitive impairment |
| spellingShingle | Dragoș-Cătălin Jianu Ligia Petrica Traian Flavius Dan Georgiana Munteanu Bianca Bora Sergiu Florin Arnăutu Sorin Ursoniu Diana Chira Ștefan Strilciuc Cristian Falup-Pecurariu Dafin Fior Mureșanu Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study Neurology International mild cognitive impairment dementia Montreal Cognitive Assessment neurology psychiatry vascular cognitive impairment |
| title | Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study |
| title_full | Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study |
| title_fullStr | Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study |
| title_full_unstemmed | Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study |
| title_short | Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry—Longer Life (IHCNP) Study |
| title_sort | evolution of cognitive disorders in patients with mild cognitive impairment mci after ischemic stroke secondary data analysis from the improved health care in neurology and psychiatry longer life ihcnp study |
| topic | mild cognitive impairment dementia Montreal Cognitive Assessment neurology psychiatry vascular cognitive impairment |
| url | https://www.mdpi.com/2035-8377/16/6/118 |
| work_keys_str_mv | AT dragoscatalinjianu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT ligiapetrica evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT traianflaviusdan evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT georgianamunteanu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT biancabora evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT sergiuflorinarnautu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT sorinursoniu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT dianachira evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT stefanstrilciuc evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT cristianfaluppecurariu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy AT dafinfiormuresanu evolutionofcognitivedisordersinpatientswithmildcognitiveimpairmentmciafterischemicstrokesecondarydataanalysisfromtheimprovedhealthcareinneurologyandpsychiatrylongerlifeihcnpstudy |