Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis.
<h4>Background</h4>Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition.<h4>Patients and methods</h4>A total of 90 neonates wi...
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262339&type=printable |
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| author | Omayma O Abdelaleem Shereen Rashad Mohammed Hassan S El Sayed Sherin Khamis Hussein Doaa Y Ali Mostafa Y Abdelwahed Sylvana N Gaber Nada F Hemeda Rehab G Abd El-Hmid |
| author_facet | Omayma O Abdelaleem Shereen Rashad Mohammed Hassan S El Sayed Sherin Khamis Hussein Doaa Y Ali Mostafa Y Abdelwahed Sylvana N Gaber Nada F Hemeda Rehab G Abd El-Hmid |
| author_sort | Omayma O Abdelaleem |
| collection | DOAJ |
| description | <h4>Background</h4>Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition.<h4>Patients and methods</h4>A total of 90 neonates with sepsis and 90 healthy neonates were enrolled in this study. qRT-PCR was performed to measure the expression levels of serum miR-34a-5p and miR-199a-3p.<h4>Results</h4>miR-34a-5p and miR-199a-3p serum levels were significantly reduced in neonates with sepsis compared with those in healthy neonates (P = 0.006 and P = 0.001, respectively). Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis.<h4>Conclusion</h4>miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment. |
| format | Article |
| id | doaj-art-b4e89eb0837b4befbde1772ce938dcae |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b4e89eb0837b4befbde1772ce938dcae2025-08-20T02:46:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171e026233910.1371/journal.pone.0262339Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis.Omayma O AbdelaleemShereen Rashad MohammedHassan S El SayedSherin Khamis HusseinDoaa Y AliMostafa Y AbdelwahedSylvana N GaberNada F HemedaRehab G Abd El-Hmid<h4>Background</h4>Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition.<h4>Patients and methods</h4>A total of 90 neonates with sepsis and 90 healthy neonates were enrolled in this study. qRT-PCR was performed to measure the expression levels of serum miR-34a-5p and miR-199a-3p.<h4>Results</h4>miR-34a-5p and miR-199a-3p serum levels were significantly reduced in neonates with sepsis compared with those in healthy neonates (P = 0.006 and P = 0.001, respectively). Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis.<h4>Conclusion</h4>miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262339&type=printable |
| spellingShingle | Omayma O Abdelaleem Shereen Rashad Mohammed Hassan S El Sayed Sherin Khamis Hussein Doaa Y Ali Mostafa Y Abdelwahed Sylvana N Gaber Nada F Hemeda Rehab G Abd El-Hmid Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. PLoS ONE |
| title | Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. |
| title_full | Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. |
| title_fullStr | Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. |
| title_full_unstemmed | Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. |
| title_short | Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis. |
| title_sort | serum mir 34a 5p and mir 199a 3p as new biomarkers of neonatal sepsis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262339&type=printable |
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