The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque
Background: Atherogenic index of plasma (AIP) is recognized as a marker for atherosclerosis, but the impact of long-term AIP exposure on carotid plaque remains unknown. Objectives: The objective of the study is to assess the associations of cumulative AIP (cumAIP), incorporating the time course of c...
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Elsevier
2025-09-01
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| Series: | JACC: Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772963X25004879 |
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| author | YanChen Zhao, MD XiaoYu Zhao, MD YunFei Li, MD YueRuiJing Liu, MD JinQi Wang, PhD JiaHe Wang, MD ZhiYuan Wu, PhD Jia Liu, PhD XiuHua Guo, PhD LiXin Tao, PhD |
| author_facet | YanChen Zhao, MD XiaoYu Zhao, MD YunFei Li, MD YueRuiJing Liu, MD JinQi Wang, PhD JiaHe Wang, MD ZhiYuan Wu, PhD Jia Liu, PhD XiuHua Guo, PhD LiXin Tao, PhD |
| author_sort | YanChen Zhao, MD |
| collection | DOAJ |
| description | Background: Atherogenic index of plasma (AIP) is recognized as a marker for atherosclerosis, but the impact of long-term AIP exposure on carotid plaque remains unknown. Objectives: The objective of the study is to assess the associations of cumulative AIP (cumAIP), incorporating the time course of cumAIP accumulation with the risk of carotid plaque. Methods: A total of 9,202 participants from the Beijing Health Management Cohort were followed up until December 31, 2021. AIP was calculated as the logarithm of the ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C). CumAIP was derived by averaging AIP values between consecutive visits and multiplying by time intervals. HRs and 95% CIs were calculated using an adjusted Cox proportional hazards model to examine the association between AIP and carotid plaque. Discordance analysis of cumAIP vs TG and HDL-C was performed using the median as the cutoff. External validation was conducted using data from the Atherosclerosis Risk in Communities study. Results: During a median follow-up of 3.99 years, 2,879 participants developed carotid plaque. The highest quartile of cumAIP was significantly associated with an increased risk of carotid plaque (HR: 1.55; 95% CI: 1.36-1.76). Both low TG/high cumAIP group (HR: 1.26; 95% CI: 1.10-1.45) and high HDL-C/high cumAIP group (HR: 1.23; 95% CI: 1.09-1.39) also showed an elevated risk for carotid plaque. Conclusions: CumAIP independently increased the risk of carotid plaque. Discordantly high cumAIP, rather than TG or HDL-C alone, poses a greater risk. Maintaining healthy AIP levels over time may be crucial for preventing atherosclerotic disease. |
| format | Article |
| id | doaj-art-b4e30adeab664cddb0bce97954756cc7 |
| institution | Kabale University |
| issn | 2772-963X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Advances |
| spelling | doaj-art-b4e30adeab664cddb0bce97954756cc72025-08-20T04:01:57ZengElsevierJACC: Advances2772-963X2025-09-014910206210.1016/j.jacadv.2025.102062The Cumulative Atherogenic Index of Plasma Exposure in Carotid PlaqueYanChen Zhao, MD0XiaoYu Zhao, MD1YunFei Li, MD2YueRuiJing Liu, MD3JinQi Wang, PhD4JiaHe Wang, MD5ZhiYuan Wu, PhD6Jia Liu, PhD7XiuHua Guo, PhD8LiXin Tao, PhD9Department of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USACapital Medical University, Yanjing Medical College, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, China; Address for correspondence: Dr Lixin Tao, Department of Epidemiology and Health Statistics, Beijing Key Laboratory of Environment and Aging, School of the Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Beijing 100069, China.Background: Atherogenic index of plasma (AIP) is recognized as a marker for atherosclerosis, but the impact of long-term AIP exposure on carotid plaque remains unknown. Objectives: The objective of the study is to assess the associations of cumulative AIP (cumAIP), incorporating the time course of cumAIP accumulation with the risk of carotid plaque. Methods: A total of 9,202 participants from the Beijing Health Management Cohort were followed up until December 31, 2021. AIP was calculated as the logarithm of the ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C). CumAIP was derived by averaging AIP values between consecutive visits and multiplying by time intervals. HRs and 95% CIs were calculated using an adjusted Cox proportional hazards model to examine the association between AIP and carotid plaque. Discordance analysis of cumAIP vs TG and HDL-C was performed using the median as the cutoff. External validation was conducted using data from the Atherosclerosis Risk in Communities study. Results: During a median follow-up of 3.99 years, 2,879 participants developed carotid plaque. The highest quartile of cumAIP was significantly associated with an increased risk of carotid plaque (HR: 1.55; 95% CI: 1.36-1.76). Both low TG/high cumAIP group (HR: 1.26; 95% CI: 1.10-1.45) and high HDL-C/high cumAIP group (HR: 1.23; 95% CI: 1.09-1.39) also showed an elevated risk for carotid plaque. Conclusions: CumAIP independently increased the risk of carotid plaque. Discordantly high cumAIP, rather than TG or HDL-C alone, poses a greater risk. Maintaining healthy AIP levels over time may be crucial for preventing atherosclerotic disease.http://www.sciencedirect.com/science/article/pii/S2772963X25004879atherosclerosiscohort studycumulative exposuretime course |
| spellingShingle | YanChen Zhao, MD XiaoYu Zhao, MD YunFei Li, MD YueRuiJing Liu, MD JinQi Wang, PhD JiaHe Wang, MD ZhiYuan Wu, PhD Jia Liu, PhD XiuHua Guo, PhD LiXin Tao, PhD The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque JACC: Advances atherosclerosis cohort study cumulative exposure time course |
| title | The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque |
| title_full | The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque |
| title_fullStr | The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque |
| title_full_unstemmed | The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque |
| title_short | The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque |
| title_sort | cumulative atherogenic index of plasma exposure in carotid plaque |
| topic | atherosclerosis cohort study cumulative exposure time course |
| url | http://www.sciencedirect.com/science/article/pii/S2772963X25004879 |
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