A study to identify novel biomarkers associated with multiple myeloma
Background. multiple myeloma (mm) is a plasma cell cancer that affects white blood cells. plasma cells from the bone marrow grow abnormally, as a consequence of which patients have high amounts of monoclonal immunoglobulin in their blood and urine, poor renal function, and recurring infections due t...
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| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2767 |
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| author | Bhaskar Kalarani Iyshwarya Veerabathiran Ramakrishnan |
| author_facet | Bhaskar Kalarani Iyshwarya Veerabathiran Ramakrishnan |
| author_sort | Bhaskar Kalarani Iyshwarya |
| collection | DOAJ |
| description | Background. multiple myeloma (mm) is a plasma cell cancer that affects white blood cells. plasma cells from the bone marrow grow abnormally, as a consequence of which patients have high amounts of monoclonal immunoglobulin in their blood and urine, poor renal function, and recurring infections due to this condition. osteolytic bone lesions and immunodeficiency also impact multiple myeloma patients’ longevity and quality of life. The disease accounts for 13 % of all hematological malignancies worldwide, making it the second most common blood cancer.Material and Methods. The studies investigating mm biomarkers from 2000 to 2021 are collected from various databases. “multiple myeloma”, “biomarkers”, “genetic markers”, “prognostic markers”, “epidemiology of multiple myeloma”, and “risk factors for multiple myeloma” are the key phrases utilized to gather the articles.Results. The scientific and medical research progressed into mm, and the number of cases increased over time and continues to rise, prompting researchers and clinicians to discover new consequences of the disease and new markers for prognosis, diagnosis, detection, and treatment of cancer in the earliest stages. Prognostic and predictive signs for illness recurrence and response to medication may be detected adequately by innovative potential biomarkers, which are more accurate than current approaches.Conclusion. treatment for multiple myeloma includes a variety of chemotherapeutic medicines, including immune modulators and proteasome inhibitors; however, most patients still experience recurrence after completing treatment. There have been numerous novel techniques for managing multiple myeloma, and this review summarises the most commonly used and the new ones that have appeared in the previously published articles. |
| format | Article |
| id | doaj-art-b4e2b05920be4b0c9247a8b2c5213c62 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-b4e2b05920be4b0c9247a8b2c5213c622025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-11-0122513414410.21294/1814-4861-2023-22-5-134-1441168A study to identify novel biomarkers associated with multiple myelomaBhaskar Kalarani Iyshwarya0Veerabathiran Ramakrishnan1Chettinad Hospital and Research Institute, Chettinad Academy of Research and EducationChettinad Hospital and Research Institute, Chettinad Academy of Research and EducationBackground. multiple myeloma (mm) is a plasma cell cancer that affects white blood cells. plasma cells from the bone marrow grow abnormally, as a consequence of which patients have high amounts of monoclonal immunoglobulin in their blood and urine, poor renal function, and recurring infections due to this condition. osteolytic bone lesions and immunodeficiency also impact multiple myeloma patients’ longevity and quality of life. The disease accounts for 13 % of all hematological malignancies worldwide, making it the second most common blood cancer.Material and Methods. The studies investigating mm biomarkers from 2000 to 2021 are collected from various databases. “multiple myeloma”, “biomarkers”, “genetic markers”, “prognostic markers”, “epidemiology of multiple myeloma”, and “risk factors for multiple myeloma” are the key phrases utilized to gather the articles.Results. The scientific and medical research progressed into mm, and the number of cases increased over time and continues to rise, prompting researchers and clinicians to discover new consequences of the disease and new markers for prognosis, diagnosis, detection, and treatment of cancer in the earliest stages. Prognostic and predictive signs for illness recurrence and response to medication may be detected adequately by innovative potential biomarkers, which are more accurate than current approaches.Conclusion. treatment for multiple myeloma includes a variety of chemotherapeutic medicines, including immune modulators and proteasome inhibitors; however, most patients still experience recurrence after completing treatment. There have been numerous novel techniques for managing multiple myeloma, and this review summarises the most commonly used and the new ones that have appeared in the previously published articles.https://www.siboncoj.ru/jour/article/view/2767multiple myelomabiomarkerstherapeutic targetsprognosis |
| spellingShingle | Bhaskar Kalarani Iyshwarya Veerabathiran Ramakrishnan A study to identify novel biomarkers associated with multiple myeloma Сибирский онкологический журнал multiple myeloma biomarkers therapeutic targets prognosis |
| title | A study to identify novel biomarkers associated with multiple myeloma |
| title_full | A study to identify novel biomarkers associated with multiple myeloma |
| title_fullStr | A study to identify novel biomarkers associated with multiple myeloma |
| title_full_unstemmed | A study to identify novel biomarkers associated with multiple myeloma |
| title_short | A study to identify novel biomarkers associated with multiple myeloma |
| title_sort | study to identify novel biomarkers associated with multiple myeloma |
| topic | multiple myeloma biomarkers therapeutic targets prognosis |
| url | https://www.siboncoj.ru/jour/article/view/2767 |
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