Molecular Signature of Gynecological Malignancies: A Narrative Review
Background: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been develo...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908188 |
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| _version_ | 1849314354113019904 |
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| author | Samah Saharti |
| author_facet | Samah Saharti |
| author_sort | Samah Saharti |
| collection | DOAJ |
| description | Background: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been developed, leading to improved survival. The fifth edition of the World Health Organization Classification of Tumors specified a diagnostic molecular pathology section under each disease category. Methods: We highlight the molecular aspects in research and diagnostics of diverse gynecological malignancies using database resources in addition to data mining software tools. Results: This review article presents insight into various gynecological cancers and their different characteristics, offering better profiling for switching to better therapeutic options. Conclusions: Genomic profiling is evolving as a clinically feasible tool for personalizing treatment. It can provide insight regarding treatment plans for common gynecological cancers. |
| format | Article |
| id | doaj-art-b4e08c3d29a443388cbbfe4dc864668a |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-b4e08c3d29a443388cbbfe4dc864668a2025-08-20T03:52:28ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-08-0149818810.31083/j.ceog4908188S0390-6663(22)01869-3Molecular Signature of Gynecological Malignancies: A Narrative ReviewSamah Saharti0Department of Pathology, Faculty of Medicine, King Abdulaziz University and King Abdulaziz University Hospital, 21589 Jeddah, Saudi ArabiaBackground: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been developed, leading to improved survival. The fifth edition of the World Health Organization Classification of Tumors specified a diagnostic molecular pathology section under each disease category. Methods: We highlight the molecular aspects in research and diagnostics of diverse gynecological malignancies using database resources in addition to data mining software tools. Results: This review article presents insight into various gynecological cancers and their different characteristics, offering better profiling for switching to better therapeutic options. Conclusions: Genomic profiling is evolving as a clinically feasible tool for personalizing treatment. It can provide insight regarding treatment plans for common gynecological cancers.https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908188molecular markersgynecological malignancieshereditary cancer syndrome |
| spellingShingle | Samah Saharti Molecular Signature of Gynecological Malignancies: A Narrative Review Clinical and Experimental Obstetrics & Gynecology molecular markers gynecological malignancies hereditary cancer syndrome |
| title | Molecular Signature of Gynecological Malignancies: A Narrative Review |
| title_full | Molecular Signature of Gynecological Malignancies: A Narrative Review |
| title_fullStr | Molecular Signature of Gynecological Malignancies: A Narrative Review |
| title_full_unstemmed | Molecular Signature of Gynecological Malignancies: A Narrative Review |
| title_short | Molecular Signature of Gynecological Malignancies: A Narrative Review |
| title_sort | molecular signature of gynecological malignancies a narrative review |
| topic | molecular markers gynecological malignancies hereditary cancer syndrome |
| url | https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908188 |
| work_keys_str_mv | AT samahsaharti molecularsignatureofgynecologicalmalignanciesanarrativereview |