Molecular Signature of Gynecological Malignancies: A Narrative Review
Background: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been develo...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908188 |
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| Summary: | Background: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been developed, leading to improved survival. The fifth edition of the World Health Organization Classification of Tumors specified a diagnostic molecular pathology section under each disease category. Methods: We highlight the molecular aspects in research and diagnostics of diverse gynecological malignancies using database resources in addition to data mining software tools. Results: This review article presents insight into various gynecological cancers and their different characteristics, offering better profiling for switching to better therapeutic options. Conclusions: Genomic profiling is evolving as a clinically feasible tool for personalizing treatment. It can provide insight regarding treatment plans for common gynecological cancers. |
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| ISSN: | 0390-6663 |