Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway

Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway

Abstract Background This study aimed to investigate the effects of Lopinavir/Ritonavir (Lop/r) on chondrocyte structure and extracellular matrix (ECM) integrity, as well as its impact on key proteins involved in anabolic and catabolic pathways, using both in vitro and in silico approaches. Methods D...

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Bibliographic Details
Main Authors: Hanefi Ozbek, Ibrahim Yilmaz, Aslı Akyuz, Suray Pehlivanoglu, Duygu Yasar Sirin, Mehmet Albayrak, Omer Faruk Yilmaz
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Chondrocyte
HIF-1α
Il-1β
Lopinavir/ritonavir
SOX9
Online Access:https://doi.org/10.1186/s13018-025-06068-5
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