The first step for understanding the molecular mechanism of the antifibrotic effect of inhaling 25(OH)-vitamin D3 and 1,25(OH)2-vitamin D3 in the murine model of hypersensitivity pneumonitis

The first step for understanding the molecular mechanism of the antifibrotic effect of inhaling 25(OH)-vitamin D3 and 1,25(OH)2-vitamin D3 in the murine model of hypersensitivity pneumonitis

IntroductionPulmonary fibrosis occurs in several respiratory diseases, among which hypersensitivity pneumonitis (HP) is often ignored in designing therapeutic strategies. We strive to fill these knowledge gaps. Our earlier studies revealed antifibrotic potential of the inhalation of 1,25(OH)2-VD3 an...

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Bibliographic Details
Main Authors: Marta Kinga Lemieszek, Michał Chojnacki, Iwona Paśnik, Alicja Wilczyńska, Wiktoria Gawryś, Jakub Anisiewicz, Ilona Leśniowska, Michał Kiełbus
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
hypersensitivity pneumonitis
epithelial–mesenchymal transition
calcidiol
calcitriol
animal models
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1610165/full
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