The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center
BACKGROUND: Infections related to cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Antibiotic-eluting envelopes have been introduced as a technology to prevent CIED infections. The aim of this study was to evaluate the effectiveness of the antiba...
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Via Medica
2025-06-01
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| Series: | Cardiology Journal |
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| Online Access: | https://journals.viamedica.pl/cardiology_journal/article/view/100458 |
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| author | Nadine Molitor Vera Graup Daniel Hofer Pascal Rüegg Deniza Avdi Ardan M. Saguner Alexander Breitenstein Jan Steffel |
| author_facet | Nadine Molitor Vera Graup Daniel Hofer Pascal Rüegg Deniza Avdi Ardan M. Saguner Alexander Breitenstein Jan Steffel |
| author_sort | Nadine Molitor |
| collection | DOAJ |
| description | BACKGROUND: Infections related to cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Antibiotic-eluting envelopes have been introduced as a technology to prevent CIED infections. The aim of this study was to evaluate the effectiveness of the antibacterial envelope in the real-world population of a tertiary center. METHODS: This cohort study includes consecutively enrolled patients undergoing a device procedure from 01/2014 to 12/2020 at the University Hospital in Zurich. During period A (01/2014-12/2019) antibacterial envelopes were not used, whereas during period B (01/2020-12/2020) antibacterial envelopes were used in all device interventions. Follow-up was conducted by assessing all available patient records from patient visits and hospitalization. RESULTS: 1757 patients (male 70.5%, mean age 67.1 ± 16 years), were analyzed during a follow-up of 24 months. In 302 patients (17.2%) an antibacterial envelope was used. The overall occurrence of a device infection was low (n = 15, 0.85%). Factors that were associated with the incidence of an infection were not undergoing a primary implantation procedure (p = 0.024) and a CRT-P/D intervention (p = 0.022). There was no difference in the rate of infection between patients in whom a bacterial envelope was implanted vs. those in whom it was not used (0.6 vs. 0.9%, p = 0.693). CONCLUSION: In a contemporary cohort of consecutive, unselected patients undergoing a device intervention at a large tertiary care center, the rate of device infection was low and not significantly different with vs. without the use of an antibacterial envelope. The data have important practical as well as economic implications for physicians performing such procedures. |
| format | Article |
| id | doaj-art-b4d8799989ab43cab45ac0d3448a1eeb |
| institution | Kabale University |
| issn | 1897-5593 1898-018X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Cardiology Journal |
| spelling | doaj-art-b4d8799989ab43cab45ac0d3448a1eeb2025-08-21T06:14:03ZengVia MedicaCardiology Journal1897-55931898-018X2025-06-0132310.5603/cj.100458The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary centerNadine Molitor0https://orcid.org/0000-0003-2544-7354Vera Graup1Daniel Hofer2Pascal Rüegg3Deniza Avdi4Ardan M. Saguner5Alexander Breitenstein6Jan Steffel7Department of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, SwitzerlandBACKGROUND: Infections related to cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Antibiotic-eluting envelopes have been introduced as a technology to prevent CIED infections. The aim of this study was to evaluate the effectiveness of the antibacterial envelope in the real-world population of a tertiary center. METHODS: This cohort study includes consecutively enrolled patients undergoing a device procedure from 01/2014 to 12/2020 at the University Hospital in Zurich. During period A (01/2014-12/2019) antibacterial envelopes were not used, whereas during period B (01/2020-12/2020) antibacterial envelopes were used in all device interventions. Follow-up was conducted by assessing all available patient records from patient visits and hospitalization. RESULTS: 1757 patients (male 70.5%, mean age 67.1 ± 16 years), were analyzed during a follow-up of 24 months. In 302 patients (17.2%) an antibacterial envelope was used. The overall occurrence of a device infection was low (n = 15, 0.85%). Factors that were associated with the incidence of an infection were not undergoing a primary implantation procedure (p = 0.024) and a CRT-P/D intervention (p = 0.022). There was no difference in the rate of infection between patients in whom a bacterial envelope was implanted vs. those in whom it was not used (0.6 vs. 0.9%, p = 0.693). CONCLUSION: In a contemporary cohort of consecutive, unselected patients undergoing a device intervention at a large tertiary care center, the rate of device infection was low and not significantly different with vs. without the use of an antibacterial envelope. The data have important practical as well as economic implications for physicians performing such procedures.https://journals.viamedica.pl/cardiology_journal/article/view/100458antibacterial envelopecardiac implantable electronic device |
| spellingShingle | Nadine Molitor Vera Graup Daniel Hofer Pascal Rüegg Deniza Avdi Ardan M. Saguner Alexander Breitenstein Jan Steffel The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center Cardiology Journal antibacterial envelope cardiac implantable electronic device |
| title | The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center |
| title_full | The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center |
| title_fullStr | The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center |
| title_full_unstemmed | The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center |
| title_short | The effect of an antibacterial envelope on cardiac implantable device-related infection — A real-world analysis from a tertiary center |
| title_sort | effect of an antibacterial envelope on cardiac implantable device related infection a real world analysis from a tertiary center |
| topic | antibacterial envelope cardiac implantable electronic device |
| url | https://journals.viamedica.pl/cardiology_journal/article/view/100458 |
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