Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance
Antimicrobial resistance is already a major global health threat, contributing to nearly 5 million deaths annually. The rise of multidrug-resistant pathogens has made many infections increasingly difficult to treat. This growing threat has driven the search for alternative therapeutic approaches. Am...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/4/414 |
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| _version_ | 1850183663549939712 |
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| author | Corina Ciobanasu |
| author_facet | Corina Ciobanasu |
| author_sort | Corina Ciobanasu |
| collection | DOAJ |
| description | Antimicrobial resistance is already a major global health threat, contributing to nearly 5 million deaths annually. The rise of multidrug-resistant pathogens has made many infections increasingly difficult to treat. This growing threat has driven the search for alternative therapeutic approaches. Among the most promising candidates are bacterial extracellular vesicles (BEVs) and antimicrobial peptides (AMPs), which offer unique mechanisms of action, potential synergistic effects, and the ability to bypass conventional resistance pathways. This review summarizes the current research on synergistic effects of BEVs and AMPs to overcome antimicrobial resistance. |
| format | Article |
| id | doaj-art-b4d852547a9847578e8cc20a7e5be8dc |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-b4d852547a9847578e8cc20a7e5be8dc2025-08-20T02:17:19ZengMDPI AGAntibiotics2079-63822025-04-0114441410.3390/antibiotics14040414Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial ResistanceCorina Ciobanasu0Department of Exact and Natural Sciences, Institute of Interdisciplinary Research, Alexandru I. Cuza University, Bulevardul Carol I, Nr. 11, 700506 Iasi, RomaniaAntimicrobial resistance is already a major global health threat, contributing to nearly 5 million deaths annually. The rise of multidrug-resistant pathogens has made many infections increasingly difficult to treat. This growing threat has driven the search for alternative therapeutic approaches. Among the most promising candidates are bacterial extracellular vesicles (BEVs) and antimicrobial peptides (AMPs), which offer unique mechanisms of action, potential synergistic effects, and the ability to bypass conventional resistance pathways. This review summarizes the current research on synergistic effects of BEVs and AMPs to overcome antimicrobial resistance.https://www.mdpi.com/2079-6382/14/4/414AMP-based therapeuticsantimicrobial peptidesantimicrobial resistancebacterial extracellular vesiclescombinatory therapymultidrug-resistant pathogens |
| spellingShingle | Corina Ciobanasu Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance Antibiotics AMP-based therapeutics antimicrobial peptides antimicrobial resistance bacterial extracellular vesicles combinatory therapy multidrug-resistant pathogens |
| title | Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance |
| title_full | Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance |
| title_fullStr | Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance |
| title_full_unstemmed | Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance |
| title_short | Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance |
| title_sort | bacterial extracellular vesicles and antimicrobial peptides a synergistic approach to overcome antimicrobial resistance |
| topic | AMP-based therapeutics antimicrobial peptides antimicrobial resistance bacterial extracellular vesicles combinatory therapy multidrug-resistant pathogens |
| url | https://www.mdpi.com/2079-6382/14/4/414 |
| work_keys_str_mv | AT corinaciobanasu bacterialextracellularvesiclesandantimicrobialpeptidesasynergisticapproachtoovercomeantimicrobialresistance |