Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies
MicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression and can modulate the composition and function of the gut microbiome, impacting metabolic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540943/full |
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| author | Lorenzo Drago Lorenzo Drago Luigi Regenburgh De La Motte Loredana Deflorio Delia Francesca Sansico Michela Salvatici Emanuele Micaglio Manuele Biazzo Fabiana Giarritiello Fabiana Giarritiello |
| author_facet | Lorenzo Drago Lorenzo Drago Luigi Regenburgh De La Motte Loredana Deflorio Delia Francesca Sansico Michela Salvatici Emanuele Micaglio Manuele Biazzo Fabiana Giarritiello Fabiana Giarritiello |
| author_sort | Lorenzo Drago |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression and can modulate the composition and function of the gut microbiome, impacting metabolic and immune processes. Conversely, the microbiome can affect host miRNA expression, influencing inflammatory pathways and disease susceptibility. This systematic review examines recent studies (2020–2024) focusing exclusively on human subjects, selected through rigorous inclusion and exclusion criteria. Studies were included if they investigated the interaction between miRNAs and the gut microbiome in the context of gastrointestinal diseases, obesity, autoimmune diseases, cognitive and neurodegenerative disorders, and autism. In vitro, in vivo and in silico analyses were excluded to ensure a strong translational focus on human pathophysiology. Notably, miRNAs, stable and abundant in patients, are emerging as promising biomarkers of microbiome-driven inflammation. This systematic review provides an overview of miRNAs, their regulatory effects on bacterial strains, and their associations with specific diseases. It also explores therapeutic advances and the potential of miRNA-based therapies to restore microbial balance and reduce inflammation. |
| format | Article |
| id | doaj-art-b4d760218ff0435095d2887ca3f8da71 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-b4d760218ff0435095d2887ca3f8da712025-02-05T07:32:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15409431540943Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologiesLorenzo Drago0Lorenzo Drago1Luigi Regenburgh De La Motte2Loredana Deflorio3Delia Francesca Sansico4Michela Salvatici5Emanuele Micaglio6Manuele Biazzo7Fabiana Giarritiello8Fabiana Giarritiello9UOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyClinical Microbiology and Microbiome Laboratory, Department of Biomedical Sciences for Health, University of Milan, Milan, ItalyUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyGenetic Consultant, IRCCS Multimedica, Milan, ItalyThe BioArte Ltd., Life Science Park, San Gwann, MaltaUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Milan, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, ItalyMicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression and can modulate the composition and function of the gut microbiome, impacting metabolic and immune processes. Conversely, the microbiome can affect host miRNA expression, influencing inflammatory pathways and disease susceptibility. This systematic review examines recent studies (2020–2024) focusing exclusively on human subjects, selected through rigorous inclusion and exclusion criteria. Studies were included if they investigated the interaction between miRNAs and the gut microbiome in the context of gastrointestinal diseases, obesity, autoimmune diseases, cognitive and neurodegenerative disorders, and autism. In vitro, in vivo and in silico analyses were excluded to ensure a strong translational focus on human pathophysiology. Notably, miRNAs, stable and abundant in patients, are emerging as promising biomarkers of microbiome-driven inflammation. This systematic review provides an overview of miRNAs, their regulatory effects on bacterial strains, and their associations with specific diseases. It also explores therapeutic advances and the potential of miRNA-based therapies to restore microbial balance and reduce inflammation.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540943/fullmiRNAgut microbiomainflammatory bowel disease (IBD)Crohn’s disease (CD)Alzheimer’s disease (AD)major depressive disorder (MDD) |
| spellingShingle | Lorenzo Drago Lorenzo Drago Luigi Regenburgh De La Motte Loredana Deflorio Delia Francesca Sansico Michela Salvatici Emanuele Micaglio Manuele Biazzo Fabiana Giarritiello Fabiana Giarritiello Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies Frontiers in Microbiology miRNA gut microbioma inflammatory bowel disease (IBD) Crohn’s disease (CD) Alzheimer’s disease (AD) major depressive disorder (MDD) |
| title | Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies |
| title_full | Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies |
| title_fullStr | Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies |
| title_full_unstemmed | Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies |
| title_short | Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies |
| title_sort | systematic review of bidirectional interaction between gut microbiome mirnas and human pathologies |
| topic | miRNA gut microbioma inflammatory bowel disease (IBD) Crohn’s disease (CD) Alzheimer’s disease (AD) major depressive disorder (MDD) |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540943/full |
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